Non-nutritive sweetened beverages versus water after a 52-week weight management programme: a randomised controlled trial.
Int J Obes (Lond)
; 48(1): 83-93, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37794246
ABSTRACT
BACKGROUND/OBJECTIVE:
Sugar-sweetened beverages are a substantial source of dietary sugar that can contribute to weight gain and the risk of type 2 diabetes. Dietary guidelines recommend non-nutritive sweetened (NNS) beverages to reduce sugar consumption, however, there is a need for long-term randomised controlled trials on their use. We aimed to compare the effects of NNS beverages and water on body weight during weight loss and maintenance in a behavioural weight management programme.METHODS:
In this parallel-group, open-label, controlled equivalence trial, adults with a BMI of 27-35 kg/m2 who regularly consumed cold beverages were randomised 11 to water or NNS beverages. Participants underwent a group behavioural weight management programme comprising weekly (during the 12-week weight-loss phase) then monthly (during the 40-week weight-maintenance phase) meetings. The primary endpoint was weight change at week 52 (equivalence two-sided P > 0.05). Secondary endpoints included changes in anthropometrics, cardiometabolic risk factors, appetite and activity levels.RESULTS:
Of 493 participants randomised (water n = 246; NNS beverages n = 247), 24.1% were NNS-naïve. At week 52, water and NNS beverages were non-equivalent, with significantly greater weight loss in the NNS beverages group. Participants consuming water maintained a weight loss of 6.1 kg over 52 weeks versus 7.5 kg with NNS beverages (difference [90% CI] 1.4 kg [-2.6, -0.2]; p < 0.05).CONCLUSIONS:
During a 52-week behavioural weight management programme, water and NNS beverages were non-equivalent, with weight loss maintained to a statistically greater extent with NNS beverages compared with water. However, this difference was not clinically significant. CLINICAL TRIAL REGISTRATION This trial is registered with ClinicalTrials.gov NCT02591134.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Programas de Redução de Peso
/
Adoçantes não Calóricos
/
Bebidas Adoçadas com Açúcar
Tipo de estudo:
Clinical_trials
/
Guideline
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Int J Obes (Lond)
Assunto da revista:
METABOLISMO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido