Localized APP expression results in progressive network dysfunction by disorganizing spike timing.

Viana da Silva, Silvia; Haberl, Matthias G; Gaur, Kshitij; Patel, Rina; Narayan, Gautam; Ledakis, Max; Fu, Maylin L; de Castro Vieira, Miguel; Koo, Edward H; Leutgeb, Jill K; Leutgeb, Stefan

Viana da Silva, Silvia; Haberl, Matthias G; Gaur, Kshitij; Patel, Rina; Narayan, Gautam; Ledakis, Max; Fu, Maylin L; de Castro Vieira, Miguel; Koo, Edward H; Leutgeb, Jill K; Leutgeb, Stefan.

Afiliação

Viana da Silva S; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA; NeuroCure Excellence Cluster and German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Haberl MG; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Neuroscience Research Center, Charitéplatz 1, 10117 Berlin, Germany.
Gaur K; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Patel R; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Narayan G; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Ledakis M; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Fu ML; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
de Castro Vieira M; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Neuroscience Research Center, Charitéplatz 1, 10117 Berlin, Germany.
Koo EH; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Leutgeb JK; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. Electronic address: jleutgeb@ucsd.edu.
Leutgeb S; Neurobiology Department, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA; Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA, USA. Electronic address: sleutgeb@ucsd.edu.

Neuron ; 112(1): 124-140.e6, 2024 Jan 03.

Article em En | MEDLINE | ID: mdl-37909036

Assuntos

Doença de Alzheimer; Precursor de Proteína beta-Amiloide; Camundongos; Humanos; Animais; Idoso; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Hipocampo/metabolismo; Neurônios/fisiologia; Doença de Alzheimer/metabolismo; Sinapses/fisiologia; Camundongos Transgênicos

Palavras-chave

Alzheimer's disease; amyloid precursor protein; hippocampus; phase precession; spike timing; theta oscillations

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Precursor de Proteína beta-Amiloide / Doença de Alzheimer Limite: Aged / Animals / Humans Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha

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