Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide.

Le, Thao D V; Liu, Dianxin; Besing, Gai-Linn K; Raghavan, Ritika; Ellis, Blair J; Ceddia, Ryan P; Collins, Sheila; Ayala, Julio E

Le, Thao D V; Liu, Dianxin; Besing, Gai-Linn K; Raghavan, Ritika; Ellis, Blair J; Ceddia, Ryan P; Collins, Sheila; Ayala, Julio E.

Afiliação

Le TDV; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.
Liu D; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Besing GK; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.
Raghavan R; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.
Ellis BJ; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.
Ceddia RP; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Collins S; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.
Ayala JE; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.

Elife ; 122023 Nov 06.

Article em En | MEDLINE | ID: mdl-37930356

Assuntos

Receptor do Peptídeo Semelhante ao Glucagon 1; Liraglutida; Proteína Regulatória Associada a mTOR; Redução de Peso; Animais; Cricetinae; Camundongos; Células CHO; Cricetulus; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Receptor do Peptídeo Semelhante ao Glucagon 1/metabolismo; Liraglutida/farmacologia; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Obesidade/tratamento farmacológico; Fosforilação; Proteína Regulatória Associada a mTOR/metabolismo

Palavras-chave

body weight; cell biology; glucagon-like peptide-1; mechanistic target of rapamycin; medicine; mouse; protein kinase A; raptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Redução de Peso / Liraglutida / Receptor do Peptídeo Semelhante ao Glucagon 1 / Proteína Regulatória Associada a mTOR Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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