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The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling.
Sharma, Deeksha; Hager, Cody G; Shang, Li; Tran, Lam; Zhu, Yongyou; Ma, Aihui; Magnuson, Brian; Lesko, Matthew W; Wicha, Max S; Burness, Monika L.
Afiliação
  • Sharma D; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Hager CG; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Shang L; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Tran L; Department of Biostatistics, University of Michigan, NCRC 26-319S, SPC 2800, 2800 Plymouth Rd, Ann Arbor, MI, USA.
  • Zhu Y; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Ma A; Elevate Bio, Cambridge, MA, USA.
  • Magnuson B; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Lesko MW; University of Delaware, Newark, DE, USA.
  • Wicha MS; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Burness ML; Department, Unit, and Laboratories, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Breast Cancer Res ; 25(1): 144, 2023 11 15.
Article em En | MEDLINE | ID: mdl-37968653
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias de Mama Triplo Negativas Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias de Mama Triplo Negativas Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos