Dexmedetomidine alleviates hippocampal neuronal loss and cognitive decline in rats undergoing open surgery under sevoflurane anaesthesia by suppressing CCAAT/enhancer-binding protein beta.

Fu, Shanshan; Zhao, Xianghai; Li, Yingna; Fan, Xinwen; Huang, Zeqing

Fu, Shanshan; Zhao, Xianghai; Li, Yingna; Fan, Xinwen; Huang, Zeqing.

Afiliação

Fu S; Department of Anesthesiology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital, Shenyang, Liaoning, China.
Zhao X; Department of Anesthesiology, Stomatological Hospital Affiliated to China Medical University, Shenyang, Liaoning, China.
Li Y; Department of Anesthesiology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital, Shenyang, Liaoning, China.
Fan X; Department of Anesthesiology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital, Shenyang, Liaoning, China.
Huang Z; Department of Anesthesiology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital, Shenyang, Liaoning, China.

Eur J Neurosci ; 59(1): 36-53, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37985440

Assuntos

Anestesia; Disfunção Cognitiva; Dexmedetomidina; Ratos; Animais; Sevoflurano/farmacologia; Dexmedetomidina/farmacologia; Dexmedetomidina/uso terapêutico; Disfunção Cognitiva/tratamento farmacológico; Disfunção Cognitiva/etiologia; Disfunção Cognitiva/metabolismo; Hipocampo/metabolismo; Inflamação/metabolismo

Palavras-chave

CEBPB; dexmedetomidine; microglia; neuroinflammation; postoperative cognitive dysfunction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dexmedetomidina / Disfunção Cognitiva / Anestesia Limite: Animals Idioma: En Revista: Eur J Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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