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How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.
Terzi, Flavia Vernin de Oliveira; Camargo, Gabriel Cordeiro; Parente, Daniella Braz; Pittella, Ana Maria; Silva-Junior, Gilberto; de Novaes, Gabrielle Gonçalves; Oliveira Neto, Jaime Araújo; Barroso, Julia Machado; Pinheiro, Martha Valéria Tavares; Xavier de Brito, Adriana Soares; de Oliveira, Renée Sarmento; Rodrigues, Rosana Souza; de Mello Perez, Renata; de Sousa, Andréa Silvestre; Moll-Bernardes, Renata Junqueira.
Afiliação
  • Terzi FVO; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Camargo GC; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Parente DB; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Pittella AM; School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
  • Silva-Junior G; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • de Novaes GG; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Oliveira Neto JA; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Barroso JM; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Pinheiro MVT; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Xavier de Brito AS; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • de Oliveira RS; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • Rodrigues RS; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • de Mello Perez R; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
  • de Sousa AS; School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
  • Moll-Bernardes RJ; D'Or Institute for Research and Education-IDOR, Rio de Janeiro 22281-100, Brazil.
J Clin Med ; 12(23)2023 Nov 29.
Article em En | MEDLINE | ID: mdl-38068433
(1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and cardiac fibrosis are important markers of mortality, but the correlation between these markers in patients with NAFLD has not been well studied. Our main objective was to determine the degree of myocardial fibrosis in patients with NAFLD and its correlation with the severity of liver fibrosis. (2) Methods: In this cross-sectional study, patients with NAFLD were allocated to two groups according to the stage of liver fibrosis assessed using MRI: no or mild fibrosis (F0-F1) and significant fibrosis (F2-F4). Framingham risk scores were calculated to evaluate cardiovascular risk factors, and patients underwent multiparametric cardiac and abdominal MRIs. (3) Results: The sample comprised 44 patients (28 with no or mild liver fibrosis and 16 with significant liver fibrosis). The mean age was 57.9 ± 12 years, and 41% were men. Most patients had high cardiac risk factors and carotid disease. Relative to patients with no or mild liver fibrosis, those with significant fibrosis had a higher median calcium score (p = 0.05) and increased myocardial extracellular volume (ECV; p = 0.02). Liver fibrosis correlated with cardiac fibrosis, represented by the ECV (r = 0.49, p < 0.001). The myocardial ECV differentiated patients with and without significant liver fibrosis (AUC = 0.78). (4) Conclusion: This study showed that diffuse myocardial fibrosis is associated with liver fibrosis in patients with NAFLD.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil