Phytosynthesis of gold-198 nanoparticles for a potential therapeutic radio-photothermal agent.

Juliyanto, Sumandi; Dita Pertiwi, Ligwina; Nurmanjaya, Ahid; Pujiyanto, Anung; Setiawan, Herlan; Rindiyantono, Fernanto; Fikri, Ahsanal; Putra, Amal Rezka; Forentin, Alfian Mahardika; Susilo, Veronika Yulianti; Febrian, Muhamad Basit; Ritawidya, Rien; Yulizar, Yoki

Juliyanto, Sumandi; Dita Pertiwi, Ligwina; Nurmanjaya, Ahid; Pujiyanto, Anung; Setiawan, Herlan; Rindiyantono, Fernanto; Fikri, Ahsanal; Putra, Amal Rezka; Forentin, Alfian Mahardika; Susilo, Veronika Yulianti; Febrian, Muhamad Basit; Ritawidya, Rien; Yulizar, Yoki.

Afiliação

Juliyanto S; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Univers
Dita Pertiwi L; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Nurmanjaya A; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Pujiyanto A; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Setiawan H; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Rindiyantono F; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Abidin; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Fikri A; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Univers
Putra AR; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Forentin AM; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Susilo VY; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Febrian MB; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Ritawidya R; Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
Yulizar Y; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia.

Appl Radiat Isot ; 204: 111141, 2024 Feb.

Article em En | MEDLINE | ID: mdl-38071856

ABSTRACT

ABSTRACT

We produced spherical gold-198 nanoparticles with an average size of 41 nm, good stability, and high radiochemical purity for a promising single agent of radio-photothermal therapy using Curcuma longa rhizome extract as a reducing and capping agent. The combination of in vitro treatment using gold-198 nanoparticles and irradiation of 980 nm wavelength lasers with a power output of 2 W/cm2 induced hyperthermia temperature and exhibited enhancement of the percentage dead on MDA-MB-123 cancer cells compared to gold-198 nanoparticles alone.

Assuntos

Radioisótopos de Ouro; Nanopartículas Metálicas; Nanopartículas; Fototerapia/métodos; Ouro; Linhagem Celular Tumoral

Palavras-chave

Cancer cells; Characterization; Gold-198 nanoparticles; Phytosynthesis; Radio-photothermal therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Nanopartículas Metálicas / Radioisótopos de Ouro Idioma: En Revista: Appl Radiat Isot Assunto da revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Ano de publicação: 2024 Tipo de documento: Article

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