Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.
JCI Insight
; 9(3)2024 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-38113104
ABSTRACT
Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component of this immune milieu, the biology and the contribution of these cells in HS pathogenesis are unclear. We aimed to investigate the dynamics and microenvironmental interactions of B cells within cutaneous HS lesions. Combining histological analysis, single-cell RNA sequencing, and spatial transcriptomics profiling of HS lesions, we defined the tissue microenvironment relative to B cell activity within this disease. Our findings identified tertiary lymphoid structures (TLSs) within HS lesions and described organized interactions among T cells, B cells, antigen-presenting cells, and skin stroma. We found evidence that B cells within HS TLSs actively underwent maturation, including participation in germinal center reactions and class switch recombination. Moreover, skin stroma and accumulating T cells were primed to support the formation of TLSs and facilitate B cell recruitment during HS. Our data definitively demonstrated the presence of TLSs in lesional HS skin and point to ongoing cutaneous B cell maturation through class switch recombination and affinity maturation during disease progression in this inflamed nonlymphoid tissue.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hidradenite Supurativa
/
Estruturas Linfoides Terciárias
Limite:
Humans
Idioma:
En
Revista:
JCI Insight
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos