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Metal-Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier.
Ge, Xueying; Mohapatra, Jeotikanta; Silva, Enya; He, Guihua; Gong, Lingshan; Lyu, Tengteng; Madhogaria, Richa P; Zhao, Xin; Cheng, Yuchuan; Al-Enizi, Abdullah M; Nafady, Ayman; Tian, Jian; Liu, J Ping; Phan, Manh-Huong; Taraballi, Francesca; Pettigrew, Roderic I; Ma, Shengqian.
Afiliação
  • Ge X; Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.
  • Mohapatra J; Engineering Medicine (EnMed), Texas A&M University and Houston Methodist Hospital, Houston, Texas, 77030, USA.
  • Silva E; Department of Physics, The University of Texas at Arlington, Arlington, Texas, 76019, USA.
  • He G; Department of Physics, University of South Florida, Tampa, Florida, 33620, USA.
  • Gong L; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
  • Lyu T; Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.
  • Madhogaria RP; Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.
  • Zhao X; Department of Physics, University of South Florida, Tampa, Florida, 33620, USA.
  • Cheng Y; J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
  • Al-Enizi AM; Zhejiang Key Laboratory of Additive Manufacturing Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
  • Nafady A; Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Tian J; Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Liu JP; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
  • Phan MH; Department of Physics, The University of Texas at Arlington, Arlington, Texas, 76019, USA.
  • Taraballi F; Department of Physics, University of South Florida, Tampa, Florida, 33620, USA.
  • Pettigrew RI; Center for Musculoskeletal Regeneration, Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston Methodist Academic Institute, Houston, Texas, 77030, USA.
  • Ma S; Engineering Medicine (EnMed), Texas A&M University and Houston Methodist Hospital, Houston, Texas, 77030, USA.
Small ; 20(12): e2306940, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38127968
ABSTRACT
The development of external stimuli-controlled payload systems has been sought after with increasing interest toward magnetothermally-triggered drug release (MTDR) carriers due to their non-invasive features. However, current MTDR carriers present several limitations, such as poor heating efficiency caused by the aggregation of iron oxide nanoparticles (IONPs) or the presence of antiferromagnetic phases which affect their efficiency. Herein, a novel MTDR carrier is developed using a controlled encapsulation method that fully fixes and confines IONPs of various sizes within the metal-organic frameworks (MOFs). This novel carrier preserves the MOF's morphology, porosity, and IONP segregation, while enhances heating efficiency through the oxidation of antiferromagnetic phases in IONPs during encapsulation. It also features a magnetothermally-responsive nanobrush that is stimulated by an alternating magnetic field to enable on-demand drug release. The novel carrier shows improved heating, which has potential applications as contrast agents and for combined chemo and magnetic hyperthermia therapy. It holds a great promise for magneto-thermally modulated drug dosing at tumor sites, making it an exciting avenue for cancer treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estruturas Metalorgânicas / Hipertermia Induzida / Antineoplásicos Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estruturas Metalorgânicas / Hipertermia Induzida / Antineoplásicos Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos