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NOP58 induction potentiates chemoresistance of colorectal cancer cells through aerobic glycolysis as evidenced by proteomics analysis.
Wang, Feifei; Yu, Bin; Yu, Quanyong; Wang, Guanglin; Li, Baokun; Guo, Ganlin; Wang, Handong; Shen, Hui; Li, Shujin; Ma, Chunling; Jia, Xianxian; Wang, Guiying; Cong, Bin.
Afiliação
  • Wang F; Hebei Key Laboratory of Forensic Medicine, Innovation Center of Forensic Medical Molecular Identification, College of Forensic Medicine, Collaborative Hebei Medical University, Shijiazhuang, Hebei, China.
  • Yu B; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Yu Q; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei, China.
  • Wang G; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Li B; China Pharmaceutical University, Nanjing, China.
  • Guo G; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Wang H; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Shen H; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Li S; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Ma C; The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Jia X; Hebei Key Laboratory of Forensic Medicine, Innovation Center of Forensic Medical Molecular Identification, College of Forensic Medicine, Collaborative Hebei Medical University, Shijiazhuang, Hebei, China.
  • Wang G; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei, China.
  • Cong B; Hebei Key Laboratory of Forensic Medicine, Innovation Center of Forensic Medical Molecular Identification, College of Forensic Medicine, Collaborative Hebei Medical University, Shijiazhuang, Hebei, China.
Front Pharmacol ; 14: 1295422, 2023.
Article em En | MEDLINE | ID: mdl-38149051
ABSTRACT

Introduction:

The majority of individuals diagnosed with advanced colorectal cancer (CRC) will ultimately acquire resistance to 5-FU treatment. An increasing amount of evidence indicates that aerobic glycolysis performs a significant function in the progression and resistance of CRC. Nevertheless, the fundamental mechanisms remain to be fully understood.

Methods:

Proteomic analysis of 5-FU resistant CRC cells was implemented to identify and determine potential difference expression protein.

Results:

These proteins may exhibit resistance mechanisms that are potentially linked to the process of aerobic glycolysis. Herein, we found that nucleolar protein 58 (NOP58) has been overexpressed within two 5-FU resistant CRC cells, 116-5FuR and Lovo-5FuR. Meanwhile, the glycolysis rate of drug-resistant cancer cells has increased. NOP58 knockdown decreased glycolysis and enhanced the sensitivity of 116-5FuR and Lovo-5FuR cells to 5FU.

Conclusion:

The proteomic analysis of chemoresistance identifies a new target involved in the cellular adaption to 5-FU and therefore highlights a possible new therapeutic strategy to overcome this resistance.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China