The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion.
J Drug Target
; 32(2): 172-185, 2024 12.
Article
em En
| MEDLINE
| ID: mdl-38155427
ABSTRACT
Introduction:
The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the Loxosceles simillis, is a demand in health. Prednisolone is one of the most used drugs, however it has side effects. In this context, addictionally gold nanoparticles (GNPs) have anti-inflammatory, antioxidant, and antibacterial properties. The use of photobiomodulation has show to be efficient in the process of tissue repair. Therefore, the purpose of this study was to investigate the anti-inflammatory effect of photobiomodulation and GNPs associated or not with a low concentration of prednisolone in animal models of dermonecrotic lesion.Methodology:
For this, rabbits with venon-induced dermonecrotic lesion were subjected to topical treatment with prednisolone + laser or GNPs + laser or Pred-GNPs + laser. The area of edema, necrosis and erythema were measured. On the last day of treatment, the animals were euthanized to remove the organs for histopathological and biochemical analysis.Results:
All treatments combinations were effective in promoting the reduction of necrotic tissue and erythema.Conclusion:
With this results, we suggest that the use of laser and nanoparticles, associated or not with prednisolone, should be considered for the treatment of dermonecrotic injury.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Venenos de Aranha
/
Terapia com Luz de Baixa Intensidade
/
Nanopartículas Metálicas
Limite:
Animals
Idioma:
En
Revista:
J Drug Target
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil