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Pseudocirrhosis: A Case Series with Clinical and Radiographic Correlation and Review of the Literature.
Sadlik, Gal; Anderson, Redmond-Craig; Lei, Xiaomeng; Cen, Steven Yong; Duddalwar, Vinay A; Fong, Tse-Ling.
Afiliação
  • Sadlik G; Department of Internal Medicine, Los Angeles County-University of Southern California Medical Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
  • Anderson RC; Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
  • Lei X; Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
  • Cen SY; Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
  • Duddalwar VA; Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
  • Fong TL; Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Dig Dis Sci ; 69(3): 1004-1014, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38175453
ABSTRACT
BACKGROUND AND

AIMS:

Pseudocirrhosis is a poorly understood acquired morphologic change of the liver that occurs in the setting of metastatic malignancy and radiographically resembles cirrhosis. Pseudocirrhosis has been primarily described in metastatic breast carcinoma, with few case reports arising from other primary malignancies. We present 29 cases of pseudocirrhosis, including several cases from primary malignancies not previously described.

METHODS:

Radiologic, clinical, demographic, and biomedical data were collected retrospectively and analyzed. We compared clinical and radiologic characteristics and outcomes between patients with pseudocirrhosis arising in metastatic breast cancer and non-breast primary malignancies.

RESULTS:

Among the 29 patients, 14 had breast cancer and 15 had non-breast primaries including previously never reported primaries associated with pseudocirrhosis, melanoma, renal cell carcinoma, appendiceal carcinoid, and cholangiocarcinoma. Median time from cancer diagnosis to development of pseudocirrhosis was 80.8 months for patients with primary breast cancer and 29.8 months for non-breast primary (p = 0.02). Among all patients, 15 (52%) had radiographic features of portal hypertension. Radiographic evidence of portal hypertension was identified in 28.6% of breast cancer patients, compared to 73.3% of those with non-breast malignancies (p = 0.03).

CONCLUSION:

Pseudocirrhosis has most commonly been described in the setting of metastatic breast cancer but occurs in any metastatic disease to the liver. Our study suggests that portal hypertensive complications are more common in the setting of non-breast primary cancers than in metastatic breast cancer. Prior exposure to multiple chemotherapeutic agents, and agents known to cause sinusoidal injury, is a common feature but not essential for the development of pseudocirrhosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Hipertensão Portal / Neoplasias Renais / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Dig Dis Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Hipertensão Portal / Neoplasias Renais / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Dig Dis Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos