Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?
Transl Psychiatry
; 14(1): 63, 2024 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-38272880
ABSTRACT
The question of whether immune dysfunction contributes to risk of psychiatric disorders has long been a subject of interest. To assert this hypothesis a plethora of correlative evidence has been accumulated from the past decades; however, a variety of technical and practical obstacles impeded on a cause-effect interpretation of these data. With the advent of large-scale omics technology and advanced statistical models, particularly Mendelian randomization, new studies testing this old hypothesis are accruing. Here we synthesize these new findings from genomics and genetic causal inference studies on the role of immune dysfunction in major psychiatric disorders and reconcile these new data with pre-omics findings. By reconciling these evidences, we aim to identify key gaps and propose directions for future studies in the field.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise da Randomização Mendeliana
/
Transtornos Mentais
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Transl Psychiatry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Noruega