Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder.
Yonsei Med J
; 65(2): 70-77, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38288647
ABSTRACT
PURPOSE:
Numerous studies have supported the role of the immune dysfunction in the pathogenesis of autism spectrum disorder (ASD); however, to our knowledge, no study has been conducted on plasma cytokine levels in children with ASD in South Korea. In this study, we aimed to analyze the immunological characteristics of Korean children with ASD through plasma cytokine analysis. MATERIALS ANDMETHODS:
Blood samples were collected from 94 ASD children (mean age 7.1; 81 males and 13 females) and 48 typically developing children (TDC) (mean age 7.3; 30 males and 18 females). Plasma was isolated from 1 mL of blood by clarifying with centrifugation at 8000 rpm at 4â for 10 min. Cytokines in plasma were measured with LEGENDplex HU Th cytokine panel (BioLegend, 741028) and LEGENDplex HU cytokine panel 2 (BioLegend, 740102).RESULTS:
Among 25 cytokines, innate immune cytokine [interleukin (IL)-33] was significantly decreased in ASD children compared with TDC. In acute phase proteins, tumor necrosis factor α (TNF-α) was significantly increased, while IL-6, another inflammation marker, was decreased in ASD children compared with TDC. The cytokines from T cell subsets, including interferon (IFN)-γ, IL-5, IL-13, and IL-17f, were significantly decreased in ASD children compared to TDC. IL-10, a major anti-inflammatory cytokine, and IL-9, which modulates immune cell growth and proliferation, were also significantly decreased in ASD children compared to TDC.CONCLUSION:
We confirmed that Korean children with ASD showed altered immune function and unique cytokine expression patterns distinct from TDC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
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Transtorno do Espectro Autista
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Yonsei Med J
Ano de publicação:
2024
Tipo de documento:
Article