Recent trends in targeted delivery of smart nanocarrier-based microbial enzymes for therapeutic applications.
Drug Discov Today
; 29(4): 103915, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38340953
ABSTRACT
Smart carrier-based immobilization has widened the use of enzymes for the treatment of several disorders. Large surface areas, tunable morphology, and surface modification ability aid the targeted and controlled release of therapeutic enzymes from such formulations. Smart nanocarriers, such as polymeric carriers, liposomes, and silica have also increased the stability, half-life, and permeability of these enzymes. In this review, summarize recent advances in the smart immobilization of microbial enzymes and their development as precision nanomedicine for the treatment of cancer, thrombosis, phenylketonuria (PKU), and wound healing. We also discuss the challenges and measures to be adopted for the successful clinical translation of these formulations.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
/
Antineoplásicos
Idioma:
En
Revista:
Drug Discov Today
/
Drug discov. today
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Drug discovery today
Assunto da revista:
FARMACOLOGIA
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TERAPIA POR MEDICAMENTOS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia