Rational design, synthesis and biological evaluation of novel HIV-1 protease inhibitors containing 2-phenylacetamide derivatives as P2 ligands with potent activity against DRV-Resistant HIV-1 variants.

Meng, Sihan; Gao, Yu; Qiang, Guowei; Hu, Zhiwei; Shan, Qi; Wang, Juxian; Wang, Yucheng; Mou, Jie

Meng, Sihan; Gao, Yu; Qiang, Guowei; Hu, Zhiwei; Shan, Qi; Wang, Juxian; Wang, Yucheng; Mou, Jie.

Afiliação

Meng S; Jiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221006, China; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Gao Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Qiang G; Jiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221006, China.
Hu Z; School of Basic Medicine, Xuzhou Medical University, Xuzhou 221006, China.
Shan Q; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Wang J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. Electronic address: imbjxwang@163.com.
Wang Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. Electronic address: wangyucheng@imb.pumc.edu.cn.
Mou J; Jiangsu Key Laboratory of New drug and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221006, China. Electronic address: mou.jie@126.com.

Bioorg Med Chem Lett ; 101: 129651, 2024 Mar 15.

Article em En | MEDLINE | ID: mdl-38342391

Assuntos

Benzenoacetamidas; Inibidores da Protease de HIV; HIV-1; Darunavir/metabolismo; Darunavir/farmacologia; HIV-1/genética; Simulação de Acoplamento Molecular; Ligantes; Protease de HIV/metabolismo; Sulfonamidas/química; Desenho de Fármacos; Cristalografia por Raios X; Relação Estrutura-Atividade

Palavras-chave

Antiviral activity; Darunavir-resistant HIV-1 protease variant; Enzymatic inhibitory activity; HIV-1 protease inhibitors; Phenylacetamide derivatives

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores da Protease de HIV / Benzenoacetamidas Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google