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Validation of biomarkers of aging.
Moqri, Mahdi; Herzog, Chiara; Poganik, Jesse R; Ying, Kejun; Justice, Jamie N; Belsky, Daniel W; Higgins-Chen, Albert T; Chen, Brian H; Cohen, Alan A; Fuellen, Georg; Hägg, Sara; Marioni, Riccardo E; Widschwendter, Martin; Fortney, Kristen; Fedichev, Peter O; Zhavoronkov, Alex; Barzilai, Nir; Lasky-Su, Jessica; Kiel, Douglas P; Kennedy, Brian K; Cummings, Steven; Slagboom, P Eline; Verdin, Eric; Maier, Andrea B; Sebastiano, Vittorio; Snyder, Michael P; Gladyshev, Vadim N; Horvath, Steve; Ferrucci, Luigi.
Afiliação
  • Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Herzog C; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA.
  • Poganik JR; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.
  • Ying K; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
  • Justice JN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Belsky DW; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Higgins-Chen AT; T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Chen BH; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Cohen AA; Department of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Fuellen G; Department of Psychiatry, Yale University, New Haven, CT, USA.
  • Hägg S; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA.
  • Marioni RE; Department of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Widschwendter M; Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.
  • Fortney K; School of Medicine, University College Dublin, Dublin, Ireland.
  • Fedichev PO; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Zhavoronkov A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Barzilai N; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
  • Lasky-Su J; Department of Women's Cancer, EGA Institute for Women's Health, University College London, London, UK.
  • Kiel DP; Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
  • Kennedy BK; BioAge Labs, Richmond, CA, USA.
  • Cummings S; Gero PTE, Singapore, Singapore.
  • Slagboom PE; Insilico Medicine Hong Kong, Hong Kong SAR, China.
  • Verdin E; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Maier AB; Department of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Sebastiano V; Musculoskeletal Research Center, Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
  • Snyder MP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Gladyshev VN; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore.
  • Horvath S; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.
  • Ferrucci L; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Nat Med ; 30(2): 360-372, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38355974
ABSTRACT
The search for biomarkers that quantify biological aging (particularly 'omic'-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic. Here, we review current efforts to evaluate the predictive validity of omic biomarkers of aging in population studies, discuss challenges in comparability and generalizability and provide recommendations to facilitate future validation of biomarkers of aging. Finally, we discuss how systematic validation can accelerate clinical translation of biomarkers of aging and their use in gerotherapeutic clinical trials.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Longevidade Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Longevidade Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos