A Pilot Study of Pembrolizumab Combined With Stereotactic Ablative Radiotherapy for Patients With Advanced or Metastatic Sarcoma.
Cancer Control
; 31: 10732748241237331, 2024.
Article
em En
| MEDLINE
| ID: mdl-38449377
ABSTRACT
OBJECTIVES:
Immunotherapy with immune checkpoint inhibitors has shown only limited success in the management of metastatic soft tissue sarcoma. Overall response rates (ORR) with single agent pembrolizumab were 18% and median PFS was 18 weeks on the clinical trial SARC028. One strategy to improve the responses to immunotherapy is with stereotactic body radiation therapy (SBRT), which can enhance the antitumor CD8 T cell response through the release of tumor-specific antigens, potentially priming a more diverse class of T cell receptors.METHODS:
This is a phase 0, pilot prospective study taking place at a single center with 2 arms. In Arm A, patients are treated with pembrolizumab 400 mg IV infusion on day 1 of a 42-day cycle. Stereotactic body radiation therapy (SBRT) is delivered in 1-5 fractions starting on C1D15-28 and given every other day. In Arm B, patients who have started an immune checkpoint inhibitor within 60 days are treated with SBRT in addition to the current therapy.RESULTS:
In this study we outline testing the feasibility of adding SBRT to pembrolizumab.CONCLUSION:
The ultimate goal of combination therapy is improved overall response, including tumors not treated with SBRT. This trial can be found registered online NCT05488366.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma
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Radiocirurgia
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Segunda Neoplasia Primária
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Anticorpos Monoclonais Humanizados
Limite:
Humans
Idioma:
En
Revista:
Cancer Control
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos