Human pluripotent stem cell-derived kidney organoids: Current progress and challenges.
World J Stem Cells
; 16(2): 114-125, 2024 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-38455108
ABSTRACT
Human pluripotent stem cell (hPSC)-derived kidney organoids share similarities with the fetal kidney. However, the current hPSC-derived kidney organoids have some limitations, including the inability to perform nephrogenesis and lack of a corticomedullary definition, uniform vascular system, and coordinated exit pathway for urinary filtrate. Therefore, further studies are required to produce hPSC-derived kidney organoids that accurately mimic human kidneys to facilitate research on kidney development, regeneration, disease modeling, and drug screening. In this review, we discussed recent advances in the generation of hPSC-derived kidney organoids, how these organoids contribute to the understanding of human kidney development and research in disease modeling. Additionally, the limitations, future research focus, and applications of hPSC-derived kidney organoids were highlighted.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
World J Stem Cells
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China