Cognitive trajectories in older adults and the role of depressive symptoms: A 7-year follow-up study.
Asian J Psychiatr
; 95: 104007, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38520944
ABSTRACT
OBJECTIVES:
To examine different trajectories of cognitive changes in elderly adults and explore the mediating role of depressive symptoms.DESIGN:
A 7-year, community-based, prospective cohort study.SETTING:
The downtown neighborhood of Shanghai, China.PARTICIPANTS:
A cohort of 394 older adults, with an average age of 71.8 years, was recruited in 2015 and has been reassessed every two years until 2021.METHODS:
Latent Class Growth Analysis was used to model aging trajectories and Linear Mixed-Effect Models for Repeated Measures were used to estimate the least squares mean changes of cognition between subjects with depression (DEP+) and without (DEP-) across all visits.RESULTS:
Three cognitive trajectories were identified the "successful aging" (SA) trajectory had the best and most consistent performance (n=229, 55.9%); the "normal aging" (NA) trajectory showed lower but stable cognition (n=141, 37.3%); while the "cognitive decline" (CD) trajectory displayed poor and declining cognition (n=24, 6.8%). Depressive symptoms were found to be influential across all trajectories. In the CD trajectory, the MoCA scores of the DEP+ group increased in within-group comparisons and were significantly higher than those of the DEP- group at visits 1 and 3 in between-group comparisons. A similar trend was observed in the NA trajectory, though it did not reach statistical significance.CONCLUSIONS:
Our research suggests that mild and decreasing depressive symptoms can be a reversible factor that might slow down the irreversible cognitive decline in the elderly. Therefore, we suggest that even mild depressive symptoms in the elderly should be monitored and detected.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Depressão
/
Disfunção Cognitiva
Limite:
Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Asian J Psychiatr
/
Asian journal of psychiatry (Online)
Ano de publicação:
2024
Tipo de documento:
Article