A Review Of Host-Specific Diagnostic And Surrogate Biomarkers In Children With Pulmonary Tuberculosis.
Paediatr Respir Rev
; 2024 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-38521643
ABSTRACT
BACKGROUND:
Tuberculosis (TB) is one of the most common causes of mortality globally with a steady rise in paediatric cases in the past decade. Laboratory methods of diagnosing TB and monitoring response to treatment have limitations. Current research focuses on interrogating host- and/or pathogen-specific biomarkers to address this problem.METHODS:
We reviewed the literature on host-specific biomarkers in TB to determine their value in diagnosis and treatment response in TB infected and HIV/TB co-infected children on anti-tuberculosis treatment. RESULTS ANDCONCLUSION:
While no single host-specific biomarker has been identified for diagnosis or treatment responses in children, several studies suggest predictive biosignatures for disease activity. Alarmingly, current data on host-specific biomarkers for diagnosing and assessing anti-tuberculosis treatment in TB/HIV co-infected children is inadequate. Various factors affecting host-specific biomarker responses should be considered in interpreting findings and designing future studies within specific clinical settings.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Paediatr Respir Rev
Assunto da revista:
PEDIATRIA
Ano de publicação:
2024
Tipo de documento:
Article