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Sociodemographic patterns in biomarkers of aging in the Add Health cohort.
Momkus, Jennifer; Aiello, Allison E; Stebbins, Rebecca; Zhang, Yuan; Harris, Kathleen Mullan.
Afiliação
  • Momkus J; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Aiello AE; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Stebbins R; Robert N. Butler Columbia Aging Center, Columbia University, New York, USA.
  • Zhang Y; Robert N. Butler Columbia Aging Center, Columbia University, New York, USA.
  • Harris KM; Robert N. Butler Columbia Aging Center, Columbia University, New York, USA.
Biodemography Soc Biol ; 69(2): 57-74, 2024.
Article em En | MEDLINE | ID: mdl-38551453
ABSTRACT
Biomarkers in population health research serve as indicators of incremental physiological deterioration and contribute to our understanding of mechanisms through which social disparities in health unfold over time. Yet, few population-based studies incorporate biomarkers of aging in early midlife, when disease risks may emerge and progress across the life course. We describe the distributions of several biomarkers of inflammation and neurodegeneration and their variation by sociodemographic characteristics using blood samples collected during Wave V of the National Longitudinal Study of Adolescent to Adult Health (ages 33-44 years). Higher mean levels of inflammatory and neurodegenerative biomarkers were associated with greater socioeconomic disadvantage. For example, the neurodegenerative markers, Neurofilament Light Chain and total Tau proteins were higher among lower income groups, though the relationship was not statistically significant. Similarly, proinflammatory marker Tumor Necrosis Factor-α (TNF-α) levels were higher among those with lower education. Significant differences in the mean levels of other proinflammatory markers were observed by race/ethnicity, sex, census region, BMI, and smoking status. These descriptive findings indicate that disparities in biomarkers associated with aging are already evident among young adults in their 30s and attention should focus on age-related disease risk earlier in the life course.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Biomarcadores Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Biodemography Soc Biol Assunto da revista: BIOLOGIA / CIENCIAS SOCIAIS / EPIDEMIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Biomarcadores Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Biodemography Soc Biol Assunto da revista: BIOLOGIA / CIENCIAS SOCIAIS / EPIDEMIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos