Cluster analysis defines four groups of Japanese patients with adult-onset Still's disease.
Mod Rheumatol
; 2024 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-38564322
ABSTRACT
OBJECTIVES:
To define groups and characterize differences in the prognosis of patients with adult-onset Still's disease (AOSD).METHODS:
We performed a retrospective cohort study. Patients with AOSD were grouped using hierarchical unsupervised cluster analysis according to age, sex, clinical features, and laboratory data. The primary endpoints were overall survival and drug-free remission rate.RESULTS:
A total of 153 patients with AOSD were placed into four clusters. Those in Cluster 1 had a young onset, tended to be female, and had fewer complications and moderate ferritin concentrations. Those in Cluster 2 had a young onset and had more complications and higher ferritin concentrations. Those in Cluster 3 had a young onset, tended to be male, and had no lymphadenopathy and fewer complications. Those in Cluster 4 had an older onset, tended to be female, and had more complications and higher ferritin concentrations. Overall survival tended to be lower (P = .0539) in Cluster 4, and drug-free remission was higher in Clusters 1, 2, and 3 [hazard ratios (HRs) 2.19, 3.37, and 3.62 vs. Cluster 4, respectively].CONCLUSIONS:
Four groups of AOSD that have distinct clinical manifestations, ferritin concentrations, severity, and drug-free remission rate were identified, which were lowest in Cluster 4. Graphical Abstract.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Mod Rheumatol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão