Affinity of structural white matter tracts between infant and adult pig.
J Neurosci Methods
; 406: 110134, 2024 06.
Article
em En
| MEDLINE
| ID: mdl-38588923
ABSTRACT
BACKGROUND:
The piglet brain has been increasingly used as an excellent surrogate for investigation of pediatric neurodevelopment, nutrition, and traumatic brain injuries. This study intends to establish a piglet brain's structural connectivity model and compare it with the adult pig, enhancing its application for structurally guided functional analysis.METHODS:
In this study, diffusion-weighted (DW)-MRI data from piglets (n=11, 3-week-old) was used to establish piglet model and compare with adult pigs. We employed a data-driven independent component analysis (ICA) method to derive piglet-specific tracts. Pearson correlations and Kullback-Leibler (KL) divergences was employed to identify common tracts and unique tracts for piglet. Common tracts were then used in a blueprint connectome study to highlight differences in regions of interest (ROI).RESULTS:
The data-driven approach applied to piglet brains revealed 17 common tracts, showing high similarity with adult pigs' white matter (WM) tracts, and identified 3 tracts unique to piglets and 10 negative marker tracts. Additionally, the study highlighted notable differences in 3 ROIs associated with blueprint connectome. COMPARING WITH EXISTINGMETHODS:
This study marks a significant shift from surface-based to voxel-based methodologies in analyzing pig brain structural connectivity and generating connectome blueprints. Additionally, it sheds light on the use of the piglet model for developmental studies, offering new perspectives in this area.CONCLUSION:
This study established a piglet brain tract model and conducts a comparative analysis of adult pig's and piglet's structural connectivity. These findings underscore the potential use of the piglet brain model in employing piglet model for developmental studies.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Conectoma
/
Substância Branca
Limite:
Animals
Idioma:
En
Revista:
J Neurosci Methods
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos