Your browser doesn't support javascript.
loading
Effect of an exercise-based cardiac rehabilitation program on quality of life of patients with chronic Chagas cardiomyopathy: results from the PEACH randomized clinical trial.
Vieira, Marcelo Carvalho; Mendes, Fernanda de Souza Nogueira Sardinha; da Silva, Paula Simplício; da Silva, Gilberto Marcelo Sperandio; Mazzoli-Rocha, Flavia; de Sousa, Andrea Silvestre; Saraiva, Roberto Magalhães; de Holanda, Marcelo Teixeira; Kasal, Daniel Arthur Barata; Costa, Henrique Silveira; Borges, Juliana Pereira; Reis, Michel Silva; Rodrigues Junior, Luiz Fernando; Hasslocher-Moreno, Alejandro Marcel; do Brasil, Pedro Emmanuel Alvarenga Americano; Mediano, Mauro Felippe Felix.
Afiliação
  • Vieira MC; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. vieiramc@yahoo.com.br.
  • Mendes FSNS; Center for Cardiology and Exercise, Aloysio de Castro State Institute of Cardiology, Rio de Janeiro, RJ, Brazil. vieiramc@yahoo.com.br.
  • da Silva PS; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • da Silva GMS; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • Mazzoli-Rocha F; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • de Sousa AS; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • Saraiva RM; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • de Holanda MT; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • Kasal DAB; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • Costa HS; Department of Research and Education, National Institute of Cardiology, Rio de Janeiro, RJ, Brazil.
  • Borges JP; Internal Medicine Department, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Reis MS; Department of Physical Therapy, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil.
  • Rodrigues Junior LF; Laboratory of Physical Activity and Health Promotion, University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.
  • Hasslocher-Moreno AM; Faculty of Physical Therapy, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • do Brasil PEAA; Department of Research and Education, National Institute of Cardiology, Rio de Janeiro, RJ, Brazil.
  • Mediano MFF; Department of Physiological Sciences, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Sci Rep ; 14(1): 8208, 2024 04 08.
Article em En | MEDLINE | ID: mdl-38589582
ABSTRACT
To investigate the effect of an exercise-based cardiac rehabilitation program on the quality of life (QoL) of patients with chronic Chagas cardiomyopathy (CCC). PEACH study was a single-center, superiority randomized clinical trial of exercise training versus no exercise (control). The sample comprised Chagas disease patients with CCC, left ventricular ejection fraction < 45%, without or with HF symptoms (CCC stages B2 or C, respectively). QoL was assessed at baseline, after three months, and at the end of six months of follow-up using the SF-36 questionnaire. Patients randomized for the exercise group (n = 15) performed exercise training (aerobic, strength and stretching exercises) for 60 min, three times a week, during six months. Patients in the control group (n = 15) were not provided with a formal exercise prescription. Both groups received identical nutritional and pharmaceutical counseling during the study. Longitudinal analysis of the effects of exercise training on QoL, considering the interaction term (group × time) to estimate the rate of changes between groups in the outcomes (represented as beta coefficient), was performed using linear mixed models. Models were fitted adjusting for each respective baseline QoL value. There were significant improvements in physical functioning (ß = + 10.7; p = 0.02), role limitations due to physical problems (ß = + 25.0; p = 0.01), and social functioning (ß = + 19.2; p < 0.01) scales during the first three months in the exercise compared to the control group. No significant differences were observed between groups after six months. Exercise-based cardiac rehabilitation provided short-term improvements in the physical and mental aspects of QoL of patients with CCC.Trial registration ClinicalTrials.gov Identifier NCT02517632; August 7, 2015.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatia Chagásica / Reabilitação Cardíaca / Insuficiência Cardíaca Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatia Chagásica / Reabilitação Cardíaca / Insuficiência Cardíaca Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil