Tofacitinib as a Rescue Therapy for Ulcerative Colitis in Pregnancy.

Rowan, Catherine; Yeaman, Fiona; Ernest-Suarez, Kenneth; Martin, Marie-Louise; Panaccione, Remo; Shukla, Tushar; Grossi, Matt; Vlasschaert, Meghan; Novak, Kerri; Seow, Cynthia

Rowan, Catherine; Yeaman, Fiona; Ernest-Suarez, Kenneth; Martin, Marie-Louise; Panaccione, Remo; Shukla, Tushar; Grossi, Matt; Vlasschaert, Meghan; Novak, Kerri; Seow, Cynthia.

Afiliação

Rowan C; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Yeaman F; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Ernest-Suarez K; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Martin ML; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Panaccione R; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Shukla T; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Grossi M; Obstetrics and Gynecology, Rockyview General Hospital, University of Calgary, Calgary, Canada.
Vlasschaert M; General Internal Medicine and Obstetric Medicine, Educational Director, OBIM, University of Calgary, Calgary, Canada.
Novak K; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.
Seow C; Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.

Inflamm Bowel Dis ; 30(5): 868-870, 2024 May 02.

Article em En | MEDLINE | ID: mdl-38591862

Tofacitinib, a potentially teratogenic nonselective Janus Kinase inhibitor was used as salvage therapy for ulcerative colitis during pregnancy with corticosteroids, maintenance ustekinumab, and rectal 5-ASA therapy. Corticosteroid-free remission ensued, resulting in term delivery without congenital malformations and avoidance of colectomy.

Assuntos

Colite Ulcerativa; Piperidinas; Complicações na Gravidez; Pirimidinas; Adulto; Feminino; Humanos; Gravidez; Colite Ulcerativa/tratamento farmacológico; Piperidinas/uso terapêutico; Complicações na Gravidez/tratamento farmacológico; Pirimidinas/uso terapêutico; Inibidores de Janus Quinases/uso terapêutico

Palavras-chave

pregnancy; tofacitinib; ulcerative colitis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Complicações na Gravidez / Pirimidinas / Colite Ulcerativa Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google