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Design, optimization and pharmaceutical characterization of wound healing film dressings with chloramphenicol and ibuprofen.
Savencu, Ioana; Iurian, Sonia; Bogdan, Catalina; Spînu, Nicoleta; Suciu, Maria; Pop, Anca; Țoc, Alexandru; Tomuța, Ioan.
Afiliação
  • Savencu I; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Iurian S; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Bogdan C; Department of Dermopharmacy and Cosmetics, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Spînu N; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Suciu M; Electron Microscopy Center 'C.Craciun', Biology and Geology Faculty, Babes-Bolyai University, Cluj-Napoca, Romania.
  • Pop A; LIME-CETATEA, National Institute for R&D of Isotopic and Molecular Technologies (INCDTIM), Cluj-Napoca, Romania.
  • Țoc A; Department of Toxicology, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Tomuța I; Department of Microbiology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Drug Dev Ind Pharm ; 50(5): 446-459, 2024 May.
Article em En | MEDLINE | ID: mdl-38622817
ABSTRACT

OBJECTIVE:

The aim of the present study was to develop and optimize a wound dressing film loaded with chloramphenicol (CAM) and ibuprofen (IBU) using a Quality by Design (QbD) approach.

SIGNIFICANCE:

The two drugs have been combined in the same dressing as they address two critical aspects of the wound healing process, namely prevention of bacterial infection and reduction of inflammation and pain related to injury.

METHODS:

Three critical formulation variables were identified, namely the ratios of Kollicoat SR 30D, polyethylene glycol 400 and polyvinyl alcohol. These variables were further considered as factors of an experimental design, and 17 formulations loaded with CAM and IBU were prepared via solvent casting. The films were characterized in terms of dimensions, mechanical properties and bioadhesion. Additionally, the optimal formulation was characterized regarding tensile properties, swelling behavior, water vapor transmission rate, surface morphology, thermal behavior, goniometry, in vitro drug release, cell viability, and antibacterial activity.

RESULTS:

The film was optimized by setting minimal values for the folding endurance, adhesive force and hardness. The optimally formulated film showed good fluid handling properties in terms of swelling behavior and water vapor transmission rate. IBU and CAM were released from the film up to 80.9% and 82.5% for 8 h. The film was nontoxic, and the antibacterial activity was prominent against Micrococcus spp. and Streptococcus pyogenes.

CONCLUSIONS:

The QbD approach was successfully implemented to develop and optimize a novel film dressing promising for the treatment of low-exuding acute wounds prone to infection and inflammation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bandagens / Cicatrização / Cloranfenicol / Ibuprofeno / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Drug Dev Ind Pharm Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Romênia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bandagens / Cicatrização / Cloranfenicol / Ibuprofeno / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Drug Dev Ind Pharm Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Romênia