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Microneedle Patch for Transdermal Sequential Delivery of KGF-2 and aFGF to Enhance Burn Wound Therapy.
He, Huacheng; Huang, Wen; Zhang, Shihui; Li, Jie; Zhang, Jian; Li, Bingxin; Xu, Jie; Luo, Yuting; Shi, Huiling; Li, Yue; Xiao, Jian; Ezekiel, Odinaka Cassandra; Li, Xiaokun; Wu, Jiang.
Afiliação
  • He H; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Huang W; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, P. R. China.
  • Zhang S; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Li J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Zhang J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Li B; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Xu J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Luo Y; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Shi H; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Li Y; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Xiao J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Ezekiel OC; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Li X; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
  • Wu J; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
Small ; 20(34): e2307485, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38623988
ABSTRACT
Severe burn wounds usually destroy key cells' functions of the skin resulting in delayed re-epithelization and wound regeneration. Promoting key cells' activities is crucial for burn wound repair. It is well known that keratinocyte growth factor-2 (KGF-2) participates in the proliferation and morphogenesis of epithelial cells while acidic fibroblast growth factor (aFGF) is a key mediator for fibroblast and endothelial cell growth and differentiation. However, thick eschar and the harsh environment of a burn wound often decrease the delivery efficiency of fibroblast growth factor (FGF) to the wound site. Therefore, herein a novel microneedle patch for sequential transdermal delivery of KGF-2 and aFGF is fabricated to enhance burn wound therapy. aFGF is first loaded in the nanoparticle (NPaFGF) and then encapsulated NPaFGF with KGF-2 in the microneedle patch (KGF-2/NPaFGF@MN). The result shows that KGF-2/NPaFGF@MN can successfully get across the eschar and sequentially release KGF-2 and aFGF. Additional data demonstrated that KGF-2/NPaFGF@MN achieved a quicker wound closure rate with reduced necrotic tissues, faster re-epithelialization, enhanced collagen deposition, and increased neo-vascularization. Further evidence suggests that improved wound healing is regulated by significantly elevated expressions of hypoxia-inducible factor-1 alpha (HIF-1ɑ) and heat shock protein 90 (Hsp90) in burn wounds. All these data proved that KGF-2/NPaFGF@MN is an effective treatment for wound healing of burns.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Queimaduras / Agulhas Limite: Animals / Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Queimaduras / Agulhas Limite: Animals / Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article