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Talaromides A-C, Bioactive Cyclic Heptapeptides from Talaromyces siglerae Isolated from a Marine Sponge.
Cho, Youbin; Park, Kyu-Hyung; Kim, Eunhee; Kim, Seungjin; Wang, Weihong; Choi, Hyukjae; Kang, Heonjoong.
Afiliação
  • Cho Y; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
  • Park KH; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
  • Kim E; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
  • Kim S; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
  • Wang W; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
  • Choi H; Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Korea.
  • Kang H; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea.
J Nat Prod ; 87(4): 1230-1234, 2024 04 26.
Article em En | MEDLINE | ID: mdl-38626456
ABSTRACT
Three new cyclic heptapeptides, talaromides A-C (1-3), were isolated from cultures produced by the fungus Talaromyces siglerae (Ascomycota), isolated from an unidentified sponge. The structures, featuring an unusual proline-anthranilic moiety, were elucidated by analysis of spectroscopic data and chemical transformations, including the advanced Marfey's method and GITC derivatization. Talaromides A and B inhibited migration activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Poríferos / Talaromyces Limite: Animals / Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Poríferos / Talaromyces Limite: Animals / Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2024 Tipo de documento: Article