Efficacy and Safety of Liraglutide in Patients With an Ileal Pouch-Anal Anastomosis and Chronic High Bowel Frequency: A Placebo-Controlled, Crossover, Proof-of-Concept Study.
Am J Gastroenterol
; 2024 May 02.
Article
em En
| MEDLINE
| ID: mdl-38668926
ABSTRACT
INTRODUCTION:
After colectomy with ileoanal pouch anastomosis (IPAA), many patients develop high bowel frequency (BF) refractory to antimotility agents, despite normal IPAA morphology. Low circulating levels of glucagon-like protein-1 (GLP-1), a modulator of gastroduodenal motility, have been reported after colectomy.METHODS:
Double-blind crossover study of 8 IPAA patients with refractory high BF treated with daily administration of the GLP-1 receptor agonist liraglutide or placebo.RESULTS:
Liraglutide, but not placebo, reduced daily BF by more than 35% ( P < 0.03).DISCUSSION:
Larger randomized controlled studies are warranted to delineate the treatment potential of GLP-1 receptor agonists in IPAA patients suffering from noninflammatory high BF.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Am J Gastroenterol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos