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Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative.
Burdick, Katherine E; Millett, Caitlin E; Yocum, Anastasia K; Altimus, Cara M; Andreassen, Ole A; Aubin, Valerie; Belzeaux, Raoul; Berk, Michael; Biernacka, Joanna M; Blumberg, Hilary P; Cleare, Anthony J; Diaz-Byrd, Claudia; Dubertret, Caroline; Etain, Bruno; Eyler, Lisa T; Forester, Brent P; Fullerton, Janice M; Frye, Mark A; Gard, Sébastien; Godin, Ophelia; Haffen, Emmanuel; Klaus, Federica; Lagerberg, Trine Vik; Leboyer, Marion; Martinez-Aran, Anabel; McElroy, Susan; Mitchell, Philip B; Olie, Emilie; Olorunfemi, Phebe; Passerieux, Christine; Peters, Amy T; Pham, Daniel L; Polosan, Mircea; Potter, Julia R; Sajatovic, Martha; Samalin, Ludovic; Schwan, Raymund; Shanahan, Megan; Solé, Brisa; Strawbridge, Rebecca; Stuart, Amanda L; Torres, Ivan; Ueland, Torrill; Vieta, Eduard; Williams, Lana J; Wrobel, Anna L; Yatham, Lakshmi N; Young, Allan H; Nierenberg, Andrew A; McInnis, Melvin G.
Afiliação
  • Burdick KE; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Millett CE; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Yocum AK; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Altimus CM; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Andreassen OA; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Aubin V; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Belzeaux R; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Berk M; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Biernacka JM; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Blumberg HP; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Cleare AJ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Diaz-Byrd C; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Dubertret C; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Etain B; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Eyler LT; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Forester BP; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Fullerton JM; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Frye MA; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Gard S; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Godin O; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Haffen E; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Klaus F; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Lagerberg TV; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Leboyer M; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Martinez-Aran A; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • McElroy S; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Mitchell PB; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Olie E; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Olorunfemi P; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Passerieux C; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Peters AT; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Pham DL; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Polosan M; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Potter JR; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Sajatovic M; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Samalin L; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Schwan R; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Shanahan M; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Solé B; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Strawbridge R; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Stuart AL; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Torres I; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Ueland T; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Vieta E; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Williams LJ; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Wrobel AL; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Yatham LN; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Young AH; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • Nierenberg AA; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
  • McInnis MG; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA (Burdick, Millett, Potter, Shanahan); University of Michigan, Ann Arbor, Michigan, USA (Yocum, Diaz-Byrd, McInnis); The Milken Institute, Washington, District of Columbia, USA (Altimus, Pham); NORMENT, Division of Menta
Focus (Am Psychiatr Publ) ; 21(4): 444-452, 2023 Oct.
Article em En | MEDLINE | ID: mdl-38694997
ABSTRACT

Objectives:

Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD.

Methods:

Thirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived "higher versus lower function" as the dependent variable and selected clinical and demographic variables as predictors.

Results:

We found high rates of functional impairment, ranging from 41 to 75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, the presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning.

Conclusions:

The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.Reprinted from Bipolar Disord 2022; 24709-719, with permission from John Wiley and Sons. Copyright © 2022.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Focus (Am Psychiatr Publ) Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Focus (Am Psychiatr Publ) Ano de publicação: 2023 Tipo de documento: Article