Temporal variations in meibomian gland structure-A pilot study.
Ophthalmic Physiol Opt
; 44(5): 894-909, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38708449
ABSTRACT
PURPOSE:
To investigate whether there is a measurable change in meibomian gland morphological characteristics over the course of a day (12 h) and over a month.METHODS:
The study enrolled 15 participants who attended a total of 11 study visits spanning a 5-week period. To assess diurnal changes in meibomian glands, seven visits were conducted on a single day, each 2 h apart. For monthly assessment, participants attended an additional visit at the same time of the day every week for three consecutive weeks. Meibography using the LipiView® II system was performed at each visit, and meibomian gland morphological parameters were calculated using custom semi-automated software. Specifically, six central glands were analysed for gland length ratio, gland width, gland area, gland intensity and gland tortuosity.RESULTS:
The average meibomian gland morphological metrics did not exhibit significant changes during the course of a day or over a month. Nonetheless, certain individual gland metrics demonstrated notable variation over time, both diurnally and monthly. Specifically, meibomian gland length ratio, area, width and tortuosity exhibited significant changes both diurnally and monthly when assessed on a gland-by-gland basis.CONCLUSIONS:
Meibomian glands demonstrated measurable structural change over short periods of time (hours and days). These results have implications for innovation in gland imaging and for developing precision monitoring of gland structure to assess meibomian gland health more accurately.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Glândulas Tarsais
Limite:
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ophthalmic Physiol Opt
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido