Investigating the molecular mechanisms of microRNA4093p in tumor progression: Towards targeted therapeutics (Review).
Int J Oncol
; 65(1)2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38757364
ABSTRACT
MicroRNAs (miRNAs) are a group of noncoding RNAs that exert master regulatory functions in post-transcriptional gene expression. Accumulating evidence shows that miRNAs can either promote or suppress tumorigenesis by regulating different target genes or pathways and may be involved in the occurrence of carcinoma. miR4093p is dysregulated in a variety of malignant cancers. It plays a fundamental role in numerous cellular biological processes, such as cell proliferation, apoptosis, migration, invasion, autophagy, angiogenesis and glycolysis. In addition, studies have shown that miR4093p is expected to become a noninvasive biomarker. Identifying the molecular mechanisms underlying miR4093pmediated tumor progression will help investigate miR4093pbased targeted therapy for human cancers. The present review comprehensively summarized the recently published literature on miR4093p, with a focus on the regulation and function of miR4093p in various types of cancer, and discussed the clinical implications of miR4093p, providing new insight for the diagnosis and treatment of cancers.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
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Progressão da Doença
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MicroRNAs
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Int J Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article