F420-dependent transformations in biosynthesis of secondary metabolites.
Curr Opin Chem Biol
; 80: 102468, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38776765
ABSTRACT
Cofactor F420 has been historically known as the "methanogenic redox cofactor". It is now recognised that F420 has essential roles in the primary and secondary metabolism of archaea and bacteria. Recent discoveries highlight the role of F420 as a redox cofactor in the biosynthesis of various natural products, including ribosomally synthesised and post-translationally modified peptides, and a new class of nicotinamide adenine dinucleotide-based secondary metabolites. With the vast availability of (meta)genomic data, the identification of uncharacterised F420-dependent enzymes offers the potential for discovering novel secondary metabolites, presenting valuable prospects for clinical and biotechnological applications.
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Base de dados:
MEDLINE
Assunto principal:
Metabolismo Secundário
Idioma:
En
Revista:
Curr Opin Chem Biol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article