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Consumption of soya isoflavones improved polycystic ovary syndrome-associated metabolic disorders in a rat model.
Xiao, Chao-Wu; Carbonel, Adriana A; Lima, Patricia D A; Hendry, Amy; Tsang, Benjamin K.
Afiliação
  • Xiao CW; Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Banting Research Centre, Ottawa, ONK1A 0K9, Canada.
  • Carbonel AA; Food and Nutrition Science Program, Department of Chemistry, Carleton University, Ottawa, ONK1S 5B6, Canada.
  • Lima PDA; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ONK1H 8L6, Canada.
  • Hendry A; Department of Morphology and Genetics, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
  • Tsang BK; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ONK1H 8L6, Canada.
Br J Nutr ; : 1-9, 2024 Jun 03.
Article em En | MEDLINE | ID: mdl-38826091
ABSTRACT
Polycystic ovary syndrome is associated with increased risks for certain metabolic disorders such as insulin resistance, non-alcoholic fatty liver disease and suppressed ovarian follicular development. This study aimed to examine whether soya isoflavones (ISF) mitigate these polycystic ovary syndrome-associated metabolic disorders in a rat model. Weanling Sprague-Dawley female rats were randomly divided into six groups and were treated with either 0 or 83 µg/d dihydrotestosterone (DHT) to induce polycystic ovary syndrome and fed diets containing 0, 0·5, or 1 g ISF/kg diet for 8 weeks. DHT treatment increased food intake, body weight gain (P < 0·001), percentage of primordial follicles (60 % v. 50·9 %, P < 0·05) and accumulation of lipid droplets in the livers. It also elevated serum total cholesterol, free cholesterol, TAG, NEFA and leptin and hepatic total cholesterol and NEFA. Additionally, DHT treatment reduced the percentage of primary follicles (13·8 % v. 30·2 %, P < 0·05), ovary weight and length (P < 0·001), as well as insulin sensitivity (P < 0·01) compared with the Control. ISF intake at 1 g/kg reduced body weight gain, serum total cholesterol, free cholesterol, NEFA, leptin and hepatic TAG and DHT-induced insulin resistance (P < 0·01). ISF intake at both levels decreased DHT-induced lipid droplet accumulation in the livers and changes in the percentages of primordial and primary follicles. Dietary soya ISF alleviated DHT-induced body weight gain, insulin resistance and hepatic lipid droplet accumulation, as well as suppressed ovarian follicular development. This suggests that the consumption of soya foods or ISF supplements may be beneficial for individuals with polycystic ovary syndrome, mitigating the associated metabolic disorders such as diabetes and non-alcoholic fatty liver disease.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Br J Nutr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Br J Nutr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá