High variance in quantification of Mycobacterium tuberculosis at low bacterial loads and with differentially detectable mycobacteria.
Antimicrob Agents Chemother
; 68(7): e0160123, 2024 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-38829050
ABSTRACT
We examined the correlation between three different methods of Mycobacterium tuberculosis quantification time to positivity (TTP), log10 CFU, and an assay to detect differentially detectable M. tuberculosis (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb (P < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carga Bacteriana
/
Mycobacterium tuberculosis
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos