Lysosomal control of the cGAS-STING signaling.

Xu, Yinfeng; Wan, Wei

Xu, Yinfeng; Wan, Wei.

Afiliação

Xu Y; Laboratory of Basic Biology, Hunan First Normal University, Changsha, China. Electronic address: yinfeng_xu0824@126.com.
Wan W; Department of Biochemistry, Zhejiang University School of Medicine, Hangzhou, China; Department of Thoracic Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: wanwei@zju.edu.cn.

Trends Cell Biol ; 34(8): 622-625, 2024 Aug.

Article em En | MEDLINE | ID: mdl-38849222

ABSTRACT

ABSTRACT

The cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway has a crucial role in combating pathogen infection. However, its aberrant activation is involved in several human disorders. Lysosomes are emerging as key negative regulators of cGAS-STING signaling. Here, we discuss the lysosomal control of cGAS-STING signaling and its implication in human disorders.

Assuntos

Lisossomos; Proteínas de Membrana; Nucleotidiltransferases; Transdução de Sinais; Humanos; Lisossomos/metabolismo; Nucleotidiltransferases/metabolismo; Proteínas de Membrana/metabolismo; Animais

Palavras-chave

STING; autophagy; cGAS; human disorders; innate immunity; lysosome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Lisossomos / Proteínas de Membrana / Nucleotidiltransferases Limite: Animals / Humans Idioma: En Revista: Trends Cell Biol Ano de publicação: 2024 Tipo de documento: Article

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