Use of Surface Plasmon Resonance Technique for Studies of Inter-domain Interactions in Ion Channels.
Methods Mol Biol
; 2796: 105-118, 2024.
Article
em En
| MEDLINE
| ID: mdl-38856898
ABSTRACT
Ion channels are transmembrane proteins essential for cellular functions and are important drug targets. Surface plasmon resonance (SPR) is a powerful technique for investigating protein-protein and protein-small molecule ligand interactions. SPR has been underutilized for studies of ion channels, even though it could provide a wealth of information on the mechanisms of ion channel regulation and aid in ion channel drug discovery. Here we provide a detailed description of the use of SPR technology for investigating inter-domain interactions in KCNH potassium-selective and voltage-gated ion channels.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ressonância de Plasmônio de Superfície
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos