Pyridine-borane complex-catalysed thioesterification: the direct conversion of carboxylic acids to thioesters.
Chem Commun (Camb)
; 60(52): 6671-6674, 2024 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-38860640
ABSTRACT
Thioesters are a common class of biologically active fragments and synthetically useful building blocks. An attractive synthetic approach would be to use simple and bench-stable carboxylic acids as a coupling partner. Herein, we present a 4-bromo pyridine-borane complex as a catalyst for the direct coupling of carboxylic acids with thiols. A wide range of thioesters with good functional group compatibility could be prepared via this metal-free approach. The merit of this strategy is exemplified by the modification of carboxylic acid-containing drugs.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article