Up-regulating GABA transporter-3 in the zona incerta prevents surgery-induced memory impairment in mice.
Neuropharmacology
; 257: 110034, 2024 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-38878858
ABSTRACT
Clinical surgery can lead to severe neuroinflammation and cognitive dysfunctions. It has been reported that astrocytes mediate memory formation and postoperative cognitive dysfunction (POCD), however, the thalamic mechanism of astrocytes in mediating POCD remains unknown. Here, we report that reactive astrocytes in zona incerta (ZI) mediate surgery-induced recognition memory impairment in male mice. Immunostaining results showed that astrocytes are activated with GABA transporter-3 (GAT-3) being down-expressed, and neurons were suppressed in the ZI. Besides, our work revealed that reactive astrocytes caused increased tonic current in ZI neurons. Up-regulating the expression of GAT-3 in astrocytes ameliorates surgery-induced recognition memory impairment. Together, our work demonstrates that the reactive astrocytes in the ZI play a crucial role in surgery-induced memory impairment, which provides a new target for the treatment of surgery-induced neural dysfunctions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação para Cima
/
Astrócitos
/
Proteínas da Membrana Plasmática de Transporte de GABA
/
Zona Incerta
/
Transtornos da Memória
Limite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Ano de publicação:
2024
Tipo de documento:
Article