Validation of the number of pulses required for TMS-EEG in the prefrontal cortex considering test feasibility.
Neuroscience
; 554: 63-71, 2024 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-39002755
ABSTRACT
BACKGROUND:
Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG), TMS-EEG, is a useful neuroscientific tool for the assessment of neurophysiology in the human cerebral cortex. Theoretically, TMS-EEG data is expected to have a better data quality as the number of stimulation pulses increases. However, since TMS-EEG testing is a modality that is examined on human subjects, the burden on the subject and tolerability of the test must also be carefully considered.METHOD:
In this study, we aimed to determine the number of stimulation pulses that satisfy the reliability and validity of data quality in single-pulse TMS (spTMS) for the dorsolateral prefrontal cortex (DLPFC). TMS-EEG data for (1) 40-pulse, (2) 80-pulse, (3) 160-pulse, and (4) 240-pulse conditions were extracted from spTMS experimental data for the left DLPFC of 20 healthy subjects, and the similarities between TMS-evoked potentials (TEP) and oscillations across the conditions were evaluated.RESULTS:
As a result, (2) 80-pulse and (3) 160-pulse conditions showed highly equivalent to the benchmark condition of (4) 240-pulse condition. However, (1) 40-pulse condition showed only weak to moderate equivalence to the (4) 240-pulse condition. Thus, in the DLPFC TMS-EEG experiment, 80 pulses of stimulations was found to be a reasonable enough number of pulses to extract reliable TEPs, compared to 160 or 240 pulses.CONCLUSIONS:
This is the first substantial study to examine the appropriate number of stimulus pulses that are reasonable and feasible for TMS-EEG testing of the DLPFC.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estudos de Viabilidade
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Eletroencefalografia
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Estimulação Magnética Transcraniana
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2024
Tipo de documento:
Article