Progesterone-modified natural cycle preparation for frozen embryo transfer.
Reprod Biomed Online
; 49(5): 104350, 2024 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-39244908
ABSTRACT
RESEARCH QUESTION Is there any difference in clinical outcomes between the progesterone-modified natural cycle (P4mNC) and hormone replacement therapy (HRT) endometrial preparation protocols after single euploid blastocyst frozen embryo transfer (FET) cycles? DESIGN:
A retrospective cohort study was performed at a single, private, high-volume fertility centre. Patients who underwent single euploid blastocyst FET between January 2017 and December 2019 were included. A total of 1933 FET cycles were reviewed, and 723 FET cycles from 548 patients met the inclusion criteria. Two groups were compared according to endometrial preparation 327 P4mNC-FET and 396 HRT-FET cycles. The primary outcome was the live birth rate. The secondary outcomes included the clinical pregnancy rate and the miscarriage rate.RESULTS:
There were no differences in the clinical pregnancy rate (50.2% versus 47.0%, Pâ¯=â¯0.688), miscarriage rate (9.8% versus 14.5%, Pâ¯=â¯0.115) and live birth rate (45.0% versus 39.6%, Pâ¯=â¯0.331) between the P4mNC-FET and HRT-FET groups after covariate adjustments.CONCLUSIONS:
There were no differences in the clinical outcomes between the P4mNC-FET and HRT-FET cycles. These results indicate that P4mNC-FET cycles produce clinical outcomes comparable to those of more traditional HRT-FET while allowing greater flexibility in the timing of embryo transfer.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Reprod Biomed Online
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Federação Russa