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Actinomycin D: inhibition of respiration and glycolysis.
Science ; 151(3713): 1007-10, 1966 Feb 25.
Article em En | MEDLINE | ID: mdl-5907287
Actinomycin D inhibited respiration and anaerobic glycolysis of human leukemic leukocytes and lowered the adenosine triphosphate content of the cells. Inhibitory effects on respiration and on RNA synthesis could not be dissociated from one another over a wide range of drug concentrations. Actinomycin D also impaired protein synthesis, probably by decreasing the availability of adenosine triphosphate and by inhibiting messenger RNA.
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Base de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Dactinomicina / Glicólise / Leucócitos Limite: Humans Idioma: En Revista: Science Ano de publicação: 1966 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Dactinomicina / Glicólise / Leucócitos Limite: Humans Idioma: En Revista: Science Ano de publicação: 1966 Tipo de documento: Article