Prostaglandin H synthase-mediated reaction of carcinogenic arylamines with tRNA and homopolyribonucleotides.
Biochem Biophys Res Commun
; 111(1): 96-103, 1983 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-6403016
ABSTRACT
Prostaglandin H synthase mediates the reaction of an extensive series of carcinogenic arylamines with tRNA. Structure-activity relationships suggest that benzidine is especially reactive due to extended conjugation between the 4,4'-diamino groups. In trapping experiments with homopolyribonucleotides, benzidine reacts with polyguanylic acid but 4-aminobiphenyl reacts with polycytidylic acid. The nitrenium ion of 4-aminobiphenyl (formed by N,O-acyltransferase activation of N-hydroxy-4-acetylaminobiphenyl) reacts primarily with polyguanylic acid and to a lesser extent with polyadenylic acid. The results suggest that arylamine activation by prostaglandin H synthase does not involve nitrenium ion formation.
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Base de dados:
MEDLINE
Assunto principal:
Polirribonucleotídeos
/
RNA de Transferência
/
Carcinógenos
/
Prostaglandina-Endoperóxido Sintases
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1983
Tipo de documento:
Article