Description of an albumin binding activity for Streptococcus suis serotype 2.
FEMS Microbiol Lett
; 147(2): 245-50, 1997 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-9119200
ABSTRACT
This study was undertaken to investigate the binding activity of Streptococcus suis serotype 2 to albumin. Using flow cytometry we observed a binding activity of S. suis to albumin for virulent as well as for avirulent isolates. Western immunoblots analysis revealed that a 39-kDa S. suis protein was responsible, at least in part, for this binding activity. This protein showed high N-terminal homology (95.6% for the first 23 residues) with a group A Streptococcus glyceraldehyde-3-phosphate dehydrogenase. Furthermore, the addition of albumin to the culture broth resulted in an increase in the virulence of S. suis strains in mice. These results suggest that an interaction with albumin could play a role in the pathogenesis of S. suis serotype 2 infections.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Estreptocócicas
/
Streptococcus suis
/
Albuminas
Limite:
Animals
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Canadá