MDR1 RNA transcripts do not indicate long-term prognosis in colorectal carcinomas.
Eur J Cancer
; 33(9): 1516-8, 1997 Aug.
Article
em En
| MEDLINE
| ID: mdl-9337699
ABSTRACT
Because P-glycoprotein expression might be associated with a more aggressive behaviour of colorectal carcinomas (Weinstein et al., Cancer Res, 1991, 51, 2720-2726), we determined the relationship between MDR1 RNA expression of the carcinomas and the survival of the patients. At a median duration of follow-up of 86 months, event-free survival of patients with MDR1 RNA-negative tumours (n = 35) was not significantly different to that of patients with MDR1 RNA positive tumours (n = 67). Among the different tumour stages, event-free survival of the patients was also independent of MDR1 gene expression of the tumours. Thus, these findings do not support the hypothesis that local aggressiveness of P-glycoprotein positive tumour cells translates into worse clinical outcome.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Biomarcadores Tumorais
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Proteínas de Neoplasias
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Eur J Cancer
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Áustria