The impact of human epidermal growth factor receptor-2 (low) status on the efficacy of first line cyclin-dependent kinase 4/6 inhibitors in advanced breast cancer.

The fact that the human epidermal growth factor receptor 2 (HER2)-low group, historically classified as HER2 negative in breast cancer histology, benefited from HER2-targeted treatments similarly to the HER2-positive group indicates that this group has a distinct histology from the HER2-0 group. The effectiveness of cyclin-dependent kinase 4/6 inhibitors, which are the standard first-line treatment for hormone receptor-positive, HER2-negative advanced breast cancer, in this newly defined histological subgroup remains a topic of debate. In our study, we examined the impact of HER2 status on the efficacy of CDK4/6 inhibitors. Our study is a retrospective, multicenter, real-world data analysis. One hundred sixty patients were included in the study. The relationship between HER2 status and other clinical-pathological features, as well as progression-free survival, was examined. Median follow-up was 20.33 ±â€…0.98 months. The mPFS could not be reached. All patients exhibited positive estrogen receptor expression. Among the patients, 111 (69.4%) were categorized as HER2-0, and 49 (30.6%) as HER2-low. The 24-month progression-free survival rates were similar between HER2-0 and HER2-low patients (60.6% vs 65.3%, hormone receptor: 1.18, CI: 0.67-2.20, P = .554). We established that the mPFS achieved with cyclin-dependent kinase 4/6 inhibitors as a first-line therapy for patients with advanced breast cancer is unaffected by HER2 status.

Investigation of related factors of operating room nurses' attitudes and awareness towards surgery-related pressure injury prevention in Turkey, Croatia, and Italy.

OBJECTIVE: The aim of this study is to examine related factors of operating room nurses' attitudes and awareness towards surgery-related pressure injury prevention in Turkey, Croatia, and Italy. METHODS: A descriptive and cross-sectional design was used. The study was conducted between March and September 2023. Data were collected with an online questionnaire created on Google Forms, consisting of a Nurse Information Form, a Surgery-related Pressure Injury Awareness Form, and the Attitude towards Pressure Ulcer Prevention Instrument. RESULTS: The sample of the study consisted of 258 operating room nurses working in Turkey, Croatia, and Italy. It was found that the majority of the participants (70.90 %) did not use a risk scale, had not received education on pressure injury prevention and treatment (58.10 %) but wanted to receive it (86 %). Mean attitude scores of operating room nurses by country were at an adequate level in Turkey (42.48 ± 4.30) but not at the desired level in Croatia (37.48 ± 3.44) and Italy (36.20 ± 4.02). While there was a significant positive relationship between the awareness and attitudes of operating room nurses in Turkey (p = 0.002) and Croatia (p < 0.001), no relationship was found between these variables of nurses in Italy (p = 0.109). A statistically significant difference was found between nurses' consideration of themselves sufficient and their attitudes and awareness in all three countries (p < 0.05). It was also determined that reading articles affected nurses' awareness in all countries. CONCLUSIONS: While operating room nurses' attitudes towards preventing pressure injuries were adequate in Turkey, it was determined that those of the nurses in Croatia and Italy were not at the desired level. Nurses should receive regular training on surgical pressure injuries to increase their awareness and to support them in implementing the recommendations of pressure injury guidelines in accordance with institutional policy.

Validity and reliability of the Turkish version of the Informant Assessment of Geriatric Delirium Scale.

Background and purpose:

Delirium is a common complication developing in el­der­ly patients. Therefore, it is important to diagnose delirium earlier. Family caregivers play an active role in early diagnosis of de­lirium and build a bridge between health pro­fessionals and patients. The purpose of this research was to achieve the validity and reliability of the Turkish version of the Informant Assessment of Geriatric Delirium Scale (I-AGeD).

This is a methodological study. The sample comprised 125 caregivers ac­cepting to participate in the study and offering care to older patients with hip fracture aged ≥60 years. Data were gathered preoperatively and on postoperative days 0, 1 and 2. After achieving the linguistic and content validity of the scale, the known-groups comparison was used to achieve its construct validity. The ROC curve analysis was made to determine the sensitivity and specificity of the scale. Item-total correlations, item analysis based on the difference between the upper 27% and lower 27%, Kuder–Richardson 20 (KR-20) coefficient and parallel forms reliability with the NEECHAM Confusion Scale were adapted to assess discriminant indices of the items in the I-AGeD.

The item-total correlation coeffi­cients of the scale ranged from 0.54 to 0.89 and KR-20 coefficient ranged from 0.09 to 0.91 depending on the measurement times. According to the ROC curve analysis, the sensitivity and specificity of the scale were ≥ 91% and ≥ 96% respectively. The parallel forms reliability analysis showed a highly significant, strong negative relation at each measurement between the I-AGeD and the NEECHAM Confusion Scale. 

The I-AGeD is valid and reliable to diagnose delirium in older Turkish patients in perioperative processes.

Análise cienciométrica de pesquisas de enfermagem sobre fratura de quadril: tendências, tópicos e perfis / Análisis cienciométrico de estudios de enfermería sobre fractura de cadera: tendencias, temas y perfiles / Scientometric analysis of nursing research on hip fracture: trends, topics, and profiles

Resumo Objetivo Bibliometria, cienciometria e outras metodologias relacionadas podem ser usadas para revelar os padrões básicos, conexões com diferentes temas e áreas e elementos demográficos de um determinado tópico da literatura. O objetivo deste estudo é revelar os padrões e tendências na pesquisa de enfermagem sobre fratura de quadril. Métodos Estudo exploratório descritivo classificado em metodologias de bibliometria, cienciometria e inteligência de negócios. A Web of Science foi a principal fonte de dados. Foram considerados artigos relacionados publicados entre 1990 e 2020. Na análise de dados abstratos, além das tabelas, análise de texto e modelos de rede usados no mapeamento bibliométrico, também foi utilizada a Alocação Latente de Dirichilet ( Latent Dirichlet Allocation -LDA) enriquecida por inteligência de negócios. Resultados Foram identificados 380 estudos sobre fratura de quadril (artigo=351, revisão=29). O número de artigos levantados apresentou tendência de crescimento a cada ano, o maior número de artigos foi publicado em 2020. Em termos de distribuição dos 380 estudos por país, Estados Unidos (n=159), Suécia (n=52) e Austrália (n=32) foram os três primeiros países. Dentre os dez temas identificados pela LDA, destacam-se os cuidados de enfermagem, mortalidade e reabilitação. Enfermagem, delirium e idoso foram as palavras-chave mais utilizadas. Fragilidade e reabilitação foram as palavras-chave introduzidas mais recentemente. Conclusão Os temas cuidados de enfermagem, reabilitação e vivências de cuidado têm sido intensamente estudados. Estudos sobre questões que ocorrem com o aumento da idade e onde o cuidado de enfermagem é importante podem ser conduzidos futuramente com uso de inteligência de negócios e bibliometria.

Resumen Objetivo Bibliometría, cienciometría y otras metodologías relacionadas pueden ser utilizadas para descubrir las pautas básicas, conexiones con diferentes temas y áreas y elementos demográficos de un determinado asunto de la literatura. El objetivo de este estudio es descubrir las pautas y tendencias en la investigación de enfermería sobre fractura de cadera. Métodos Estudio exploratorio descriptivo clasificado en metodologías de bibliometría, cienciometría e inteligencia de negocios. La principal fuente de datos fue Web of Science. Se consideraron artículos relacionados publicados entre 1990 y 2020. En el análisis de datos abstractos, además de cuadros, análisis de texto y modelos de red utilizados en el mapeo bibliométrico, también se usó la Asignación Latente de Dirichlet ( Latent Dirichlet Allocation , LDA) enriquecida por inteligencia de negocios. Resultados Se identificaron 380 estudios sobre fractura de cadera (artículo=351, revisión=29). El número de artículos recopilados presentó una tendencia de crecimiento cada año, la mayor cantidad de artículos fue publicada en 2020. En términos de distribución por país de los 380 estudios, Estados Unidos (n=159), Suecia (n=52) y Australia (n=32) fueron los tres primeros países. Entre los diez temas identificados por la LDA, se destacaron cuidados de enfermería, mortalidad y rehabilitación. Enfermería, delirium y adulto mayor fueron las palabras clave más utilizadas. Fragilidad y rehabilitación fueron las palabras clave introducidas más recientemente. Conclusión Los temas cuidados de enfermería, rehabilitación y vivencias de cuidado fueron estudiados intensamente. Estudios sobre cuestiones que surgen con el aumento de la edad y donde los cuidados de enfermería son importantes pueden ser conducidos con el uso de inteligencia de negocios y bibliometría en un futuro.

Abstract Objective Bibliometrics, scientometrics and other related methodologies can be used to reveal the basic patterns, links to different subjects and areas, and demographic elements of a particular topic within the literature. The aim of this study is to reveal the patterns and trends in nursing research on hip fracture. Methods This descriptive exploratory study can be classified in methodologies of bibliometrics, scientometrics and business intelligence. The Web of Science was the main data source. Related articles published between 1990 and 2020 were considered. In addition to tables, text analytics, and network models used in bibliometric mapping, Latent Dirichlet Allocation (LDA) enriched by business intelligence was utilized in the analysis of abstract data. Results The total of 380 studies on hip fracture were identified (article=351, review=29). The number of retrieved articles exhibit an increasing trend by year, the highest number of articles was published in 2020. In terms of distribution of the 380 studies by country, the United States ( n =159), Sweden ( n =52) and Australia ( n =32) were the top three countries. Among the ten topics identified by LDA, nursing care, mortality, and rehabilitation were the prominent ones. Nursing, delirium, and elderly were the most frequently used keywords. Frailty and rehabilitation were the most recently introduced keywords. Conclusion The topics of nursing care, rehabilitation and care experiences have been studied intensively. Studies on issues that may occur with increasing age and where nursing care is important can be conducted in the future using business intelligence and bibliometric.

Postoperative Constipation Incidence and Effects of Selected Risk Factors on Constipation Development in Elderly Patients With Hip Fracture.

Constipation is a common problem in the general population and is particularly prevalent among hospitalized elderly patients with hip fracture due to lack of mobility, medications, and lack of privacy associated with hospitalization. This study aimed to determine the incidence of postoperative constipation and the effects of selected risk factors on constipation development in elderly patients with hip fracture. The study used a descriptive, cross-sectional, and prospective design. Data were collected on the second postoperative day and upon discharge. The study sample included 150 patients. The constipation incidence rate was found to be 77.70%. Of all the patients developing constipation, 87.70% did not have a normal bowel movement even upon discharge. A significant difference was found between constipation development and the total score for constipation risk assessment, postponing defecation, psychological or behavioral barriers to defecation in the hospital environment, preservation of privacy for defecation, and return to normal bowel movement upon discharge. Based on the results, nurses should determine the risk factors for constipation unique to each patient in the postoperative period and conduct appropriate preventive interventions.

Validity and reliability of the Turkish version of the lymphedema symptom intensity and distress survey.

OBJECTIVES: This study aims to adapt the Lymphedema Symptom Intensity and Distress Survey- Arm (LSIDS-Arm) into Turkish and to test its validity and reliability. PATIENTS AND METHODS: Between September 2017 and July 2018, this descriptive, methodological study included a total of 186 women (mean age: 55.4±10.2 years; range, 20 to 80 years) who were diagnosed with breast cancer-related lymphedema (BCRL) and followed in the lymphedema outpatient clinic. Data were collected using sociodemographic and clinical features form, LSIDS-Arm, and Functional Assessment of Cancer Treatment-Breast Cancer Scale+4 (FACT-B+4). After the linguistic and content validity of the scale was achieved, confirmatory factor analysis and known-groups validation were utilized to test the construct validity. Reliability of the survey was tested using the Cronbach alpha and Spearman Brown coefficient, item analysis, and parallel forms reliability. RESULTS: All patients completed the questionnaire. After achievement of linguistic and content validity, confirmatory factor analysis results were found to be higher than the accepted value. Known-groups validation revealed a significant difference in the mean scores for the intensity and distress scales between the patients with and without lymphedema. Cronbach alpha for the subscales ranged from 0.61 to 0.86. Parallel forms reliability showed a moderate, significant correlation between subscales of the intensity and distress scales of the survey and the subscales of FACT-B+4. CONCLUSION: The Turkish version of the survey is valid and reliable and can be used to evaluate symptoms, severity of symptoms, and distress caused by BCRL symptoms in the Turkish women.

The Effect of Selected Risk Factors on Perioperative Pressure Injury Development.

Patients undergoing operative and other invasive procedures are at high risk for developing pressure injuries. This study aimed to determine the incidence of perioperative pressure injuries in patients who underwent procedures lasting two hours or more in Turkey and the risk factors that affect the development of pressure injuries. Data were collected during the perioperative period. The incidence of perioperative pressure injuries was 40.4%. The results of univariate logistic regression analysis showed that intraoperative vasopressor use, skin turgor, and diastolic blood pressure less than or equal to 60 mm Hg were significantly related to the development of pressure injuries. There was no significant difference between patients who developed pressure injuries and patients who did not when comparing their preoperative Braden Scale scores. Perioperative nurses should assess each patient for pressure injury risk and perform interventions to prevent pressure injuries during each stage of the patient's perioperative course.

Investigation of inadvertent hypothermia incidence and risk factors.

OBJECTIVE: This study was conducted to determine the incidence of inadvertent hypothermia in operative patients and the risk factors that are involved in the development of hypothermia. MATERIAL AND METHODS: This prospective, descriptive, cross-sectional study was conducted from January 2016to August 2016 with 144 patients who over the age of 18 years, underwent general surgery, orthopedic surgery, urologic surgery, neurosurgery, and plastic and reconstructive surgery. Data was collected with the "Hypothermia Data Collection Form." Body temperature was measured by the tympanic membrane in the waiting room, operating room, and PACU. RESULTS: Overall, 89% of the patients (n=129) were normothermic in the preoperative phase; 74.30% of the patients (n=107) in intraoperative phase and 75.70% of the patients (n=109) in postoperative phase were hypothermic. American Society of Anesthesiologist (ASA) score, preoperative body temperature, operating room temperature, and using heating method at operation were found to be effective in the development of inadvertent hypothermia during the operating period. It was determined that premedication, preoperative and postoperative body temperature, and the operating room temperature were effective for inadvertent hypothermia in the postoperative period. CONCLUSION: As a result of the study, it was determined the rate of inadvertent hypothermia was high during and after surgery. Preoperative and intraoperative patient body temperature and operating room temperature were found to be effective in preventing inadvertent hypothermia.