METABOLIC THERAPY IN THE COMPLEX TREATMENT OF CHRONIC PANCREATITIS WITH STABLE CORONARY ARTERY DISEASE.

OBJECTIVE: The aim: To study the effectiveness of using medicine meldonium in standard therapy to the correction of prooxidant-antioxidant and kallikrein-kinin disorders in patients with chronic pancreatitis andstable coronary artery disease. PATIENTS AND METHODS: Materials and methods: The study included 90 patients with chronic pancreatitis andstable coronary artery disease.They were divided into two groups: I group (45 patients) received standard treatment; II group (45 patients) along with basic therapy received medication meldonium (Vazonat) for 2 capsules (500 mg) once daily for two months. Indicators prooxidant-antioxidant system in blood plasma was determined by biochemical method, indicators of kallikrein-kinin system- by chromatographic method. RESULTS: Results: The better status of the prooxidant-antioxidant system and kallikrein-kinin system was observed in patients who received in addition to standard protocol treatment with meldonium. CONCLUSION: Conclusions: Adding to the complex therapy of patients with chronic pancreatitis and stable coronary artery disease of the medicine meldonium helps to improve the prooxidation-antioxidant status and disorders in the kallikrein-kinin system more significantly compared with standard basic therapy.

Kallikrein-kinin system disbalance in chronic pancreatis in combination with metabolic syndrome.

OBJECTIVE: Inroduction: Disbalance of kallikrein-kinin system, which is present in patients with chronic pancreatitis, is quite often associated with metabolic syndrome. The aim: to study and compare the status of kallicrein-kinin system in patients with chronic pancreatitis compared with patients with comorbidity of chronic pancreatitis and metabolic syndrome. PATIENTS AND METHODS: Materials and methods: All patients were divided into two groups: I group included 58 patients with chronic pancreatitis in combination with metabolic syndrome; IІ group included 32 patients with chronic pancreatitis. . Indicators of kallicrein-kinin system in blood plasma were determined by chromatographic method. Results and conclusions: Worse condition of kallicrein-kinin system was observed in patients with metabolic syndrome. Patients with chronic pancreatitis with comorbidity with metabolic syndrome established more pronounced activation of the system of general and specific proteolysis with statistically significantly higher rates of proteolytic activity of plasma, kallikrein, α1-protease inhibitor and kininase-II (p<0.05) relative to patients with chronic pancreatitis.

Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis.

OBJECTIVE: Inroduction: The urgency of the problem of chronic pancreatitis is increasing due to the fact that in 70.0% - 90.0% of cases of diseases of the digestive system are accompanied by pathology of other organs and systems, also including helminthiasis, especially ascariasis. The aim: to study and compare the quality of life of patients with chronic pancreatitis in regarding to patients with comorbidity of chronic pancreatitis and ascariasis. PATIENTS AND METHODS: Materials and methods: the study included 53 patients with chronic pancreatitis with ascariasis and 30 patients with isolated chronic pancreatitis. The quality of life of all patients were evaluated by using a common medical questionnaire - the Medical Outcomes Study 36-Item, and a specialized gastroenterological questionnaire the Gastrointestinal Symptom Rating Scale. RESULTS: Results: during the study, in patients with comorbidity of chronic pancreatitis with ascariasis a lower quality of life was established. The quality of life in patients with chronic pancreatitis and ascariasis was significantly reduced by both the general questionnaire SF-36 and the specific questionnaire GSRS in comparison with patients with isolated chronic pancreatitis. CONCLUSION: Conclusions: patients with chronic pancreatitis concomitant with ascariasis had a significantly lower level of quality of life scores on all scales as by a questionnaire Medical Outcomes Study 36-Item and by gastroenterological questionnaire the Gastrointestinal Symptom Rating Scale in regarding to the group of patients with chronic pancreatitis.