Anticandidal Effect of New Imidazole Derivatives Over Aspartic Protease Inhibition.

Candidiasis is one of the most serious microbial infections in the world. One of the main virulence factors for Candida albicans is the crucial secretion of aspartic proteases (Saps). Saps are hydrolytic enzymes that play a major role in many fungal pathophysiological processes as well as in many levels of the associations between the fungus and its host. In this work, we report on the synthesis, characterization, and anti-candida agent evaluation of a family of 13 imidazolidine-based aspartate protease inhibitors. In vitro and in silico enzyme inhibition studies have confirmed these compounds' ability to inhibit fungal aspartate protease. Based on the molecular mechanistic value scores from molecular docking and MD simulations, we selected the top compounds 5b (binding energy -13.90 kcal/mol) and 5m (binding energy -12.94 kcal/mol) from among 5a-l based on the molecular mechanistic value scores from molecular docking and MD simulations for use in in vitro validations. In the results, imidazolidine derivatives showed strong aspartic protease inhibition activity. In conclusion, compounds 5b and 5m were found as potent anti-candida agents and screened for further pre-clinical and clinical validations.

A Novel partial sequence technique based Chaotic biogeography optimization for PAPR reduction in eneralized frequency division multiplexing waveform.

For Orthogonal Frequency Division Multiplexing (OFDM) systems, the most significant problem is the peak-to-average power ratio. The utilisation of partial transmission sequence, often known as PTS, is an efficient method for reducing PAPR. When it comes to minimizing the peak-to-average power ratio (PAPR) in Orthogonal Frequency Division Multiplexing (OFDM) Systems, PTS is one of the most effective approaches that may be used. Due to the substantial data load, using peak-to-average power ratio in OFDM is challenging. The most crucial problem with OFDM is achieving better results by lowering PAPR. Provide a PTS in this research that is based on the Chaotic Biogeography Based Optimization (CBBO) algorithm to effectively address the high PAPR issue that exists in Generalized Frequency Division Multiplexing (GFDM) waveforms using Hermitian Symmetry property is used. The Hermitian symmetry is utilised in order to acquire a real-valued time-domain signal. Phase rotation factor combinations are carried out in an effective and optimal manner through the utilisation of an innovative combination of optimization techniques. In comparison to conventional optimization techniques, a new hybrid optimization offers quick convergence quality and minimal complexity. When compared to traditional PTS methods such traditional GFDM and OFDM-PTS, experimental results demonstrate that the suggested CBBO-PTS technique significantly improves on minimizing PAPR.

Standardization of biopolymer production from seaweed associative bacteria.

Polyhydroxyalkanoate (PHA) is the biodegradable plastic, which is shown the similar properties to the synthetic plastic. Production of PHA is expensive when compared with petrochemical based plastics costs and also hazardous to ecosystem. In order to overcome these drawbacks, some cheaper commercially available carbon sources like rice bran, coconut cake, palm jaggary, etc. can be used. The present study aimed to identify the potential PHA producing bacterial strains from different seaweeds. Based on PHA production and crotonic acid assay, two bacterial strains were screened and designated as M3 and S6 which were found to be efficient PHA producers. Potential PHA producers of M3 and S6 were identified as Bacillus cereus RBL6 and Pseudomonas pseudoalcaligens RBL7 by 16S rRNA gene sequencing. The physical and nutritional parameters such as pH, temperature, incubation period, substrate, carbon and nitrogen concentration have been used for enhancing PHA production which was served as precursor. The purified PHA had been chemically characterized by FT-IR, GC-MS and viewed through SEM.