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1.
Materials (Basel) ; 16(6)2023 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-36984052

RESUMO

The behaviour of the steel bar in concrete under cyclic loading has been evaluated using magnetic flux leakage associated with acoustic emission monitoring technique. Visual observation was used to observe the deformation of the beam under cyclic loading. The sensors of metal magnetic memory were scanned in the middle of the beam at a distance of 320 mm at the bottom part. Twenty-two cyclic ranges were performed for cyclic loading of 100 or 200 cycles for each range, with a frequency of 1 Hz and a sinusoidal wave mode. The magnetic flux leakage signal, acoustic emission characteristics and crack width were measured and analysed to evaluate the behaviour of the steel bar in the concrete beam. The magnetic flux leakage signal and acoustic emission energy results were well matched with the occurrence of cracks at the centre of the beam. It was found that the relationship between the magnetic leakage flux signal and crack opening showed a strong correlation with R2 of 0.969. A high acoustic emission energy of 1300 nVs is observed at the centre of the beam. Based on the results, the behaviour of the steel in the concrete beam can be determined by the integrity assessment of a structure.

2.
Materials (Basel) ; 16(3)2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36769942

RESUMO

The purpose of this paper is to determine the best dimple core design for metal sandwich panels by investigating the various critical criteria and core design parameters using the fuzzy-hybrid multi-criteria decision-making tool. The structural integrity of a sandwich panel depends on the core design and significantly affects the bonding strength. The continuous design and testing of a sandwich panel is a very lengthy process that increases the design time. The simulation analysis output was segregated into nine critical failure criteria. All the critical criteria weightages were evaluated using the Fuzzy-Analytical Hierarchical Process, while the Fuzzy-Technique for Order Preference by Similarity to Ideal Solution was used to evaluate the Closeness Coefficient value to determine the best core design configuration. The results indicate that the core configuration with a diameter of 6.0 mm and a depth of 3.0 mm obtained the highest closeness coefficient values, 0.9937 and 0.9294, under cyclic loading conditions of 50% and 70%. It was shown that using average sizes in the dimple configuration tends to provide better delamination resistance and structural integrity. This study contributes to the selection of the optimum core design configuration based on the various design criteria and using non-complex and competent analysis.

3.
Materials (Basel) ; 16(2)2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36676201

RESUMO

This paper presents a modified fatigue life model of the Basquin equation using the stress parameter of the magnetic flux leakage signal. Most pipeline steels experience cyclic loading during service and the influence of the load history makes assessing fatigue behaviour more difficult. The magnetic flux leakage signal's response to a uniaxial cyclic test of API X65 steel was measured with eight levels of ultimate tensile stress loads. The influence of dH(y)/dx on fatigue failure was the main concern in this study, the aim being to represent localised stress parameters in the modified Basquin equation. Both fatigue lives, experimental and predicted from the modified Basquin equation, were validated through reliability analysis, producing a 60% value when approaching 1.8 × 105 cycles. The fatigue data from the experiment produced a higher mean-cycle-to-failure value than the prediction data, with slightly different values of 3.37 × 105 and 3.28 × 105. Additionally, the modified Basquin equation's predicted and the experimental fatigue lives were found to have a high R2 correlation value of 0.9022. The Pearson correlation also showed a good relationship between the fatigue lives, with an r value of 0.9801. Finally, the modified Basquin equation based on dH(y)/dx signals provided an accurate and alternative method for durability assessment.

4.
Materials (Basel) ; 16(1)2023 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-36614795

RESUMO

The aim of this paper is to characterise the fatigue reliability for various random strain loads under extreme value distribution while considering the cycle sequence effect condition in fatigue life prediction. The established strain-life models, i.e., Morrow and Smith-Watson-Topper, considered a mean stress effect and strain amplitude; nevertheless, it excluded the load sequence effect, which involves the fatigue crack closure that is subjected to overload or underload. A FESEM-EDX analysis is conducted to characterise the failure features that occurred on the leaf spring. A finite element is simulated to determine the critical region in order to obtain the strain load behaviour. In addition, the strain signal is captured experimentally at 500 Hz for 100 s under operating conditions for three different road loads based on the critical location obtained from the finite element analysis. The fatigue life correlation shows that the Pearson correlation coefficients are greater than 0.9, which indicates the effective strain damage model is linearly correlated with the strain-life models. The fatigue life data are modelled using extreme value distribution by considering the random strain loads as extreme data. The reliability rate for the fatigue life is reported to be more than 0.59 within the hazard rate range of 9.6 × 10-8 to 1.2 × 10-7 based on the mean cycle to the failure point. Hence, the effective strain damage model is proposed for a fatigue reliability assessment under extreme conditions with higher reliability and provides fatigue life prediction when subjected to cycle sequence effects.

5.
Materials (Basel) ; 15(14)2022 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-35888355

RESUMO

Vibration fatigue characteristics are critical for rotating machinery components such as turbine rotor blades. Lattice structures are gaining popularity in engineering applications due to their unique ability to reduce weight and improve the mechanical properties. This study is an experimental investigation of octet-truss lattice structure utilization in turbine rotor blades for weight reduction and to improve vibration fatigue characteristics. One completely solid and three lattice infilled blades with variable strut thickness were manufactured via additive manufacturing. Both free and forced experimental vibration analyses were performed on the blades to investigate their modal and vibration fatigue characteristics. The blades were subjected to random vibration using a vibration shaker. The response was measured using a triaxial accelerometer in terms of vibration acceleration time histories in the X, Y, and Z directions. Results indicate a weight reduction of up to 24.91% and enhancement in the first natural frequency of up to 5.29% were achieved using lattice infilled blades. The fatigue life of the blades was investigated using three frequency domain approaches, namely, Lalanne, Dirlik and narrow band. The fatigue life results indicate that the 0.25 mm lattice blade exhibits the highest fatigue life, while the solid blade exhibits the lowest fatigue life of all four blades. The fatigue life of the 0.25 mm lattice blade was 1822-, 1802-, and 1819- fold higher compared to that of the solid blade, using the Lalanne, Dirlik, and narrow-band approaches, respectively. These results can serve as the first step towards the utilization of lattice structures in turbine blades, with thermal analysis as the next step. Therefore, apart from being light weight, the octet-truss lattice infilled blades exhibited superior vibration fatigue characteristics to vibration loads, thereby making them a potential replacement for solid blades in turbine rotors.

6.
Polymers (Basel) ; 13(3)2021 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-33573112

RESUMO

Moisture absorption tests for materials that exhibit non-Fickian behavior generally require a relatively long period to reach saturation. Therefore, it would be beneficial to establish a relationship between the moisture content and the thickness to minimize the experimental time and cost. This research characterizes the moisture absorption behavior of AS4/8552 carbon/epoxy composites. Specimens were prepared at 4, 8, and 16 plies and immersed in distilled water at 60 °C. The relationship between the non-Fickian parameters (Fickian to non-Fickian maximum moisture content ratio ϕ, non-Fickian diffusivity per square thickness α, and non-Fickian initiation time to) and thickness was characterized using a thickness-dependent model. A comparison with other materials revealed that all three non-Fickian parameters are able to be fitted using a power law. Nevertheless, the upper boundary for the applicability of this model was not determined in this study. The Weibull distribution plots indicate that the probability of non-Fickian moisture absorption is influenced by ϕ and α at approximately 62% within a normalized thickness range of 2-3. In regards to to, it is 82% at a normalized thickness of 6. Therefore, the Weibull distribution is proposed for the assessment of non-Fickian moisture absorption based on the material's thickness.

8.
Materials (Basel) ; 12(13)2019 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-31262020

RESUMO

This study investigated the different thicknesses of TiO2 photoanode films and the effect of surface plasmon resonance (SPR) of Ag-TiO2 nanocomposites on the current-voltage (I-V) performance of dye-sensitized solar cells (DSSC). The TiO2 layer was deposited using the doctor blade technique and the thickness of the TiO2 films was controlled by using a different number of Scotch tape layers. The silver nanoparticles (AgNP) were synthesised using a chemical reduction method and the concentration of sodium citrate as a reducing agent was varied from 4 to 12 mM to study the effect of citrate ion on the size of the nanoparticles. Ag-TiO2 nanopowder was prepared by adding pure anatase TiO2 powder into AgNP colloidal solution. The mixture was left to dry for 24 h to obtain Ag-TiO2 powder for paste preparation. The three-layer Scotch tape, with thickness of 14.38 µm, achieved a high efficiency of 4.14%. This results showed that three layers was the optimal thickness to improve dye loading and to reduce the charge recombination rate. As for the Ag-TiO2 nanocomposites, 10 mM of AgNP, with a mean diameter of 65.23 nm and high efficiency of 6.92%, proved that SPR can enhance the absorption capability of dye and improve the photon-to-electron generation.

9.
Entropy (Basel) ; 22(1)2019 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-33285783

RESUMO

This paper presents the assessment of fatigue crack growth rate for dual-phase steel under spectrum loading based on entropy generation. According to the second law of thermodynamics, fatigue crack growth is related to entropy gain because of its irreversibility. In this work, the temperature evolution and crack length were simultaneously measured during fatigue crack growth tests until failure to ensure the validity of the assessment. Results indicated a significant correlation between fatigue crack growth rate and entropy. This relationship is the basis in developing a model that can determine the characteristics of fatigue crack growth rates, particularly under spectrum loading. Predictive results showed that the proposed model can accurately predict the fatigue crack growth rate under spectrum loading in all cases. The root mean square error in all cases is 10-7 m/cycle. In conclusion, entropy generation can accurately predict the fatigue crack growth rate of dual-phase steels under spectrum loading.

10.
J Healthc Eng ; 2017: 1631384, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29138687

RESUMO

Biceps brachii muscle illness is one of the common physical disabilities that requires rehabilitation exercises in order to build up the strength of the muscle after surgery. It is also important to monitor the condition of the muscle during the rehabilitation exercise through electromyography (EMG) signals. The purpose of this study was to analyse and investigate the selection of the best mother wavelet (MWT) function and depth of the decomposition level in the wavelet denoising EMG signals through the discrete wavelet transform (DWT) method at each decomposition level. In this experimental work, six healthy subjects comprised of males and females (26 ± 3.0 years and BMI of 22 ± 2.0) were selected as a reference for persons with the illness. The experiment was conducted for three sets of resistance band loads, namely, 5 kg, 9 kg, and 16 kg, as a force during the biceps brachii muscle contraction. Each subject was required to perform three levels of the arm angle positions (30°, 90°, and 150°) for each set of resistance band load. The experimental results showed that the Daubechies5 (db5) was the most appropriate DWT method together with a 6-level decomposition with a soft heursure threshold for the biceps brachii EMG signal analysis.


Assuntos
Traumatismos do Braço/reabilitação , Braço/fisiologia , Contração Muscular , Músculo Esquelético/fisiologia , Adulto , Eletromiografia , Terapia por Exercício , Feminino , Voluntários Saudáveis , Humanos , Masculino , Amplitude de Movimento Articular , Suporte de Carga , Adulto Jovem
11.
BMC Complement Altern Med ; 15: 58, 2015 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-25887391

RESUMO

BACKGROUND: Post-menopausal osteoporosis has long been treated and prevented by estrogen replacement therapy (ERT). Despite its effectiveness, ERT is associated with serious adverse effects. Labisia pumila var. alata (LP) is a herb with potential as an alternative agent to ERT due to its phytoestrogenic, antioxidative and anti-inflammatory effects on bone. This study aimed to determine the effects of LP supplementation on bone biomechanical strength of postmenopausal osteoporosis rat model. METHODS: Ninety-six female Sprague-Dawley rats aged 4 to 5 months old were randomly divided into six groups; six rats in the baseline group (BL) and eighteen rats in each group of; Sham- operated (Sham), ovariectomised control (OVXC) and ovariectomised with daily oral gavages of Premarin at 64.5 µg/kg (ERT), LP at 20 mg/kg (LP20) and LP at 100 mg/kg (LP100) respectively. These groups were subdivided into three, six and nine weeks of treatment periods. Rats in BL group were euthanized before the start of the study, while other rats were euthanized after completion of their treatments. Femora were dissected out for biomechanical strength analysis using Instron Universal Model 5848 Micro Tester. RESULTS: OVXC group showed deterioration in the bone biomechanical strength with time. Both ERT and LP supplemented rats showed improvements in bone strength parameters such as maximum load, displacement, stiffness, stress, and Young Modulus. The most improved bone strength was seen in rats given LP at the dose of 100 mg/kg for nine weeks. CONCLUSION: LP supplementation at 100 mg/kg was more effective than ERT in reversing ovariectomy-induced bone biomechanical changes.


Assuntos
Fêmur/efeitos dos fármacos , Osteoporose Pós-Menopausa/tratamento farmacológico , Fitoestrógenos/uso terapêutico , Fitoterapia , Extratos Vegetais/uso terapêutico , Primulaceae , Animais , Fenômenos Biomecânicos , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Feminino , Fêmur/patologia , Humanos , Osteoporose Pós-Menopausa/etiologia , Osteoporose Pós-Menopausa/patologia , Ovariectomia , Fitoestrógenos/farmacologia , Extratos Vegetais/farmacologia , Ratos Sprague-Dawley , Estresse Mecânico
12.
PLoS One ; 9(12): e115595, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25526611

RESUMO

Osteoporosis is becoming a major health problem that is associated with increased fracture risk. Previous studies have shown that osteoporosis could delay fracture healing. Although there are potential agents available to promote fracture healing of osteoporotic bone such as statins and tocotrienol, studies on direct delivery of these agents to the fracture site are limited. This study was designed to investigate the effects of two potential agents, lovastatin and tocotrienol using targeted drug delivery system on fracture healing of postmenopausal osteoporosis rats. The fracture healing was evaluated using micro CT and biomechanical parameters. Forty-eight Sprague-Dawley female rats were divided into 6 groups. The first group was sham-operated (SO), while the others were ovariectomized (OVx). After two months, the right tibiae of all rats were fractured at metaphysis region using pulsed ultrasound and were fixed with plates and screws. The SO and OVxC groups were given two single injections of lovastatin and tocotrienol carriers. The estrogen group (OVx+EST) was given daily oral gavages of Premarin (64.5 µg/kg). The Lovastatin treatment group (OVx+Lov) was given a single injection of 750 µg/kg lovastatin particles. The tocotrienol group (OVx+TT) was given a single injection of 60 mg/kg tocotrienol particles. The combination treatment group (OVx+Lov+TT) was given two single injections of 750 µg/kg lovastatin particles and 60 mg/kg tocotrienol particles. After 4 weeks of treatment, the fractured tibiae were dissected out for micro-CT and biomechanical assessments. The combined treatment group (OVx+Lov+TT) showed significantly higher callus volume and callus strength than the OVxC group (p<0.05). Both the OVx+Lov and OVx+TT groups showed significantly higher callus strength than the OVxC group (p<0.05), but not for callus volume. In conclusion, combined lovastatin and tocotrienol may promote better fracture healing of osteoporotic bone.


Assuntos
Consolidação da Fratura/efeitos dos fármacos , Lovastatina/administração & dosagem , Osteoporose Pós-Menopausa/complicações , Fraturas da Tíbia/diagnóstico por imagem , Fraturas da Tíbia/tratamento farmacológico , Tocotrienóis/administração & dosagem , Animais , Fenômenos Biomecânicos , Modelos Animais de Doenças , Sistemas de Liberação de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Lovastatina/uso terapêutico , Osteoporose Pós-Menopausa/diagnóstico por imagem , Ratos , Ratos Sprague-Dawley , Resistência à Tração/efeitos dos fármacos , Fraturas da Tíbia/complicações , Tocotrienóis/uso terapêutico , Resultado do Tratamento , Microtomografia por Raio-X/métodos
13.
Clinics (Sao Paulo) ; 67(9): 1077-85, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23018307

RESUMO

OBJECTIVE: Osteoporosis increases the risk of bone fractures and may impair fracture healing. The aim of this study was to investigate whether alpha-tocopherol can improve the late-phase fracture healing of osteoporotic bones in ovariectomized rats. METHOD: In total, 24 female Sprague-Dawley rats were divided into three groups. The first group was sham-operated, and the other two groups were ovariectomized. After two months, the right femora of the rats were fractured under anesthesia and internally repaired with K-wires. The sham-operated and ovariectomized control rat groups were administered olive oil (a vehicle), whereas 60 mg/kg of alpha-tocopherol was administered via oral gavage to the alpha-tocopherol group for six days per week over the course of 8 weeks. The rats were sacrificed, and the femora were dissected out. Computed tomography scans and X-rays were performed to assess fracture healing and callus staging, followed by the assessment of callus strengths through the biomechanical testing of the bones. RESULTS: Significantly higher callus volume and callus staging were observed in the ovariectomized control group compared with the sham-operated and alpha-tocopherol groups. The ovariectomized control group also had significantly lower fracture healing scores than the sham-operated group. There were no differences between the alpha-tocopherol and sham-operated groups with respect to the above parameters. The healed femora of the ovariectomized control group demonstrated significantly lower load and strain parameters than the healed femora of the sham-operated group. Alpha-tocopherol supplementation was not able to restore these biomechanical properties. CONCLUSION: Alpha-tocopherol supplementation appeared to promote bone fracture healing in osteoporotic rats but failed to restore the strength of the fractured bone.


Assuntos
Antioxidantes/farmacologia , Consolidação da Fratura/efeitos dos fármacos , Fraturas Ósseas/tratamento farmacológico , Osteoporose Pós-Menopausa , alfa-Tocoferol/farmacologia , Animais , Fenômenos Biomecânicos , Densidade Óssea , Modelos Animais de Doenças , Feminino , Fêmur/diagnóstico por imagem , Fêmur/efeitos dos fármacos , Humanos , Osteoporose Pós-Menopausa/diagnóstico por imagem , Ovariectomia , Maleabilidade , Radiografia , Ratos , Ratos Sprague-Dawley , Resistência à Tração , Fatores de Tempo , Tomógrafos Computadorizados
14.
Artigo em Inglês | MEDLINE | ID: mdl-22991574

RESUMO

Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis. However, ERT causes serious side effects, such as cancers and thromboembolic problems. Labisia pumila var. alata (LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures. This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model. Thirty-two female rats were randomly divided into four groups: Sham-operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var. alata (LP), and ovariectomized with ERT (Premarin) (ERT). The LPva and ERT were administered via oral gavage daily at doses of 17.5 mg/kg and 64.5 µg/kg, respectively. Following two months of treatment, the rats were euthanized, and their right femora were prepared for bone biomechanical testing. The results showed that ovariectomy compromised the femoral strength, while LPva supplementation to the ovariectomized rats improved the femoral strength. Therefore, LPva may be as effective as ERT in preventing fractures due to estrogen-deficient osteoporosis.

15.
Clinics ; 67(9): 1077-1085, Sept. 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-649389

RESUMO

OBJECTIVE: Osteoporosis increases the risk of bone fractures and may impair fracture healing. The aim of this study was to investigate whether alpha-tocopherol can improve the late-phase fracture healing of osteoporotic bones in ovariectomized rats. METHOD: In total, 24 female Sprague-Dawley rats were divided into three groups. The first group was sham-operated, and the other two groups were ovariectomized. After two months, the right femora of the rats were fractured under anesthesia and internally repaired with K-wires. The sham-operated and ovariectomized control rat groups were administered olive oil (a vehicle), whereas 60 mg/kg of alpha-tocopherol was administered via oral gavage to the alpha-tocopherol group for six days per week over the course of 8 weeks. The rats were sacrificed, and the femora were dissected out. Computed tomography scans and X-rays were performed to assess fracture healing and callus staging, followed by the assessment of callus strengths through the biomechanical testing of the bones. RESULTS: Significantly higher callus volume and callus staging were observed in the ovariectomized control group compared with the sham-operated and alpha-tocopherol groups. The ovariectomized control group also had significantly lower fracture healing scores than the sham-operated group. There were no differences between the alpha-tocopherol and sham-operated groups with respect to the above parameters. The healed femora of the ovariectomized control group demonstrated significantly lower load and strain parameters than the healed femora of the sham-operated group. Alpha-tocopherol supplementation was not able to restore these biomechanical properties. CONCLUSION: Alpha-tocopherol supplementation appeared to promote bone fracture healing in osteoporotic rats but failed to restore the strength of the fractured bone.


Assuntos
Animais , Feminino , Humanos , Ratos , Antioxidantes/farmacologia , Consolidação da Fratura/efeitos dos fármacos , Fraturas Ósseas/tratamento farmacológico , Osteoporose Pós-Menopausa , alfa-Tocoferol/farmacologia , Fenômenos Biomecânicos , Densidade Óssea , Modelos Animais de Doenças , Fêmur/efeitos dos fármacos , Fêmur , Ovariectomia , Osteoporose Pós-Menopausa , Maleabilidade , Ratos Sprague-Dawley , Resistência à Tração , Fatores de Tempo , Tomógrafos Computadorizados
16.
Artigo em Inglês | MEDLINE | ID: mdl-22829855

RESUMO

This study investigated the effects of α-tocopherol and palm oil tocotrienol supplementations on bone fracture healing in postmenopausal osteoporosis rats. 32 female Sprague-Dawley rats were divided into four groups. The first group was sham operated (SO), while the others were ovariectomised. After 2 months, the right femora were fractured under anesthesia and fixed with K-wire. The SO and ovariectomised-control rats (OVXC) were given olive oil (vehicle), while both the alpha-tocopherol (ATF) and tocotrienol-enriched fraction (TEF) groups were given alpha-tocopherol and tocotrienol-enriched fraction, respectively, at the dose of 60 mg/kg via oral gavages 6 days per week for 8 weeks. The rats were then euthanized and the femora dissected out for bone biomechanical testing to assess their strength. The callous of the TEF group had significantly higher stress parameter than the SO and OVXC groups. Only the SO group showed significantly higher strain parameter compared to the other treatment groups. The load parameter of the OVXC and ATF groups was significantly lower than the SO group. There was no significant difference in the Young's modulus between the groups. In conclusion, tocotrienol is better than α-tocopherol in improving the biomechanical properties of the fracture callous in postmenopausal osteoporosis rat model.

17.
J Orthop Res ; 28(12): 1651-6, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20572125

RESUMO

Fracture healing is a complex process, which is further complicated if the bone is osteoporotic. Calcium is one of the important minerals in bone and has been found to prevent osteoporosis but its role in fracture healing of osteoporotic bone is still unclear. We carried out a study on the effects of calcium supplementation on the late phase healing of fractured osteoporotic bone using an ovariectomized rat model. Twenty-four female Sprague-Dawley rats were divided into three groups: sham-operated (SO), ovariectomized-control (OVXC), and ovariectomized + calcium supplements (Ca). The right femurs of all the rats were fractured at mid-epiphysis and a K-wire was inserted for internal fixation. After 2 months of treatment, the rats were sacrificed and the femora were dissected out for radiological and biomechanical assessment. As expected, osteoporosis resulted in impaired healing as shown by the poor radiological and biomechanical properties of the OVXC group. CT scans showed significantly lower callus volumes in the SO and Ca groups compared to the OVXC group. Radiological scoring of fracture healing and callus staging of the SO and Ca groups were better than the OVXC group. However, the biomechanical parameters of the Ca group were significantly lower than the SO group and similar to the OVXC group. Therefore, calcium supplements may appear to improve fracture healing of osteoporotic bone but failed to improve strength.


Assuntos
Cálcio da Dieta/farmacologia , Fraturas do Fêmur/terapia , Consolidação da Fratura/efeitos dos fármacos , Animais , Fenômenos Biomecânicos , Calo Ósseo/efeitos dos fármacos , Feminino , Fraturas do Fêmur/complicações , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Fêmur/tratamento farmacológico , Osteoporose/complicações , Ratos , Ratos Sprague-Dawley , Tomografia Computadorizada por Raios X
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